Synthesis of new 8-arylisoquinoline derivatives by application of palladium-catalyzed Suzuki cross-coupling reactions

被引：8
|
作者：
Andreu, I
Cabedo, N
Fabis, F
Cortes, D
Rault, S
机构：
[1] Univ Caen, Ctr Etudes & Rech Medicament Normandie, UFR Sci Pharmaceut, F-14032 Caen, France
[2] Univ Valencia, Fac Farm, Dept Farmacol, Lab Farmacognosia, E-46100 Valencia, Spain
来源：
TETRAHEDRON | 2005年 / 61卷 / 34期
关键词：
8-bromotetrahydroisoquinoline; Friedel-Crafts cyclization; 8-aryltetrahydroisoquinolines; Suzuki cross-coupling reactions;
D O I：
10.1016/j.tet.2005.06.025
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New 8-(het)aryltetrahydroisoquinolines (10-14), 8-aryltetrahydroisoquinolin-4-ols (15,16), and 8-phenylisoquinolin-4-ol (17), flexible analogues of aporphine, were synthesized in good yields using palladium-catalyzed Suzuki cross-coupling reactions from 8-bromotetrahydroisoquinotin-4-one (6) as a common intermediate. We also describe the synthesis of this novel intermediate through an easy and efficient method, which involved intramolecular Friedel-Crafts cyclization. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8282 / 8287
页数：6
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