Rasagiline improves freezing in a patient with primary progressive freezing gait

被引：13

作者：

Coria, Francisco ^{[1
,2
]}

Cozar-Santiago, Maria del Puig ^{[3
]}

机构：

[1] Hosp Univ Son Duerta, Clin Nervous Syst Disorders, Palma de Mallorca, Spain

[2] Hosp Univ Son Duerta, Serv Neurol, Palma de Mallorca, Spain

[3] Clin Rotger, Inst Nucl Med, Palma de Mallorca, Spain

来源：

MOVEMENT DISORDERS | 2008年 / 23卷 / 03期

关键词：

freezing of gait; primary progressive freezing gait; MAOB inhibitors; rasagiline; brain perfusion SPECT;

D O I：

10.1002/mds.21868

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We herein report the case of a 84-year-old man with a 4-year history of freezing of gait (FOG) consistent with the diagnosis of primary progressive freezing gait. Single photon emission tomography (SPECT) with a radiolabeled ligand of the dopamine transporter (DAT-SPECT) showed integrity of striatal dopaminergic terminals, whereas brain perfusion SPECT disclosed multiple areas of decreased perfusion in frontal and parietal lobes, as well as in the subcortical gray nuclei of both sides. Treatment with the new irreversible monoamine oxidase B inhibitor rasagiline at standard doses resulted in a rapid, dramatic, and sustained improvement of the frequency and duration of FOG episodes. In addition, brain perfusion SPECT after treatment showed a marked increase of the activity in all cortical areas as well as in the basal ganglia and thalamus. Rasagiline may prove to be an effective and safe treatment for this disabling condition. (C) 2007 Movement Disorder Society.

引用

页码：449 / 451

页数：3

共 50 条

[31] Heterogeneous pathogenesis of primary progressive freezing gait: Insights from imaging of the dopamine transporter
Fasano, A.
Baldari, S.
Di Giuda, D.
Paratore, R.
Piano, C.
Bentivoglio, A. R.
Girlanda, P.
Morgante, F.
MOVEMENT DISORDERS, 2012, 27 : S249 - S249
[32] Pedunculopontine nucleus deep brain stimulation in primary progressive freezing of gait: A case study
Ostrem, J. L.
Christine, C. W.
Volz, M. M.
Glass, G. A.
Larson, P. S.
Schrock, L. E.
Starr, P. A.
MOVEMENT DISORDERS, 2008, 23 (01) : S380 - S380
[33] Two cases of primary progressive freezing gait with different chronologic progression and different imaging
Kim, M.
Son, E.
Choi, S.
Lee, K.
Lee, S.
Park, M.
Cho, K.
MOVEMENT DISORDERS, 2007, 22 : S208 - S208
[34] Syndrome of primary progressive freezing gait: A study of striatal dopamine transporter and of response to treatment
Alunar-Beaugendre, Y.
Itti, E.
Lefaucheur, J. -P.
Remys, P.
Fenelon, G.
MOVEMENT DISORDERS, 2010, 25 (07) : S498 - S498
[35] Zolpidem ameliorates the freezing of gait in a patient with PAGF (pure akinesia with freezing of gait)-the possible neural mechanism
Tsai, C. -H.
Huang, H. -C.
Duann, J. -R.
Liu, B. -L.
Lin, H. -C.
Lu, M. -K.
Chen, J. -C.
MOVEMENT DISORDERS, 2016, 31 : S76 - S77
[36] Modulation of gait symmetry by subthalamic stimulation improves intractable freezing of gait
Fasano, A.
Stolze, H.
Volkmann, J.
Deuschl, G.
Herzog, J.
MOVEMENT DISORDERS, 2009, 24 : S525 - S525
[37] Pedunculopontine nucleus deep brain stimulation produces sustained improvement in primary progressive freezing of gait
Wilcox, Robert A.
Cole, Michael H.
Wong, David
Coyne, Terry
Silburn, Peter
Kerr, Graham
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2011, 82 (11): : 1256 - 1259
[38] Primary progressive freezing gait disorder (PPFG): A neuroimaging study to evaluate dopamine transporter density
Jennings, DL
Factor, SA
Molho, ES
Friedman, JH
Innis, RB
Seibyl, JP
Marek, KL
NEUROLOGY, 2000, 54 (07) : A191 - A191
[39] Freezing of gait is an early clinical feature of progressive supranuclear palsy
Osaki, Y.
Morita, Y.
Miyamoto, Y.
Furushima, T.
Furuta, K.
Furuya, H.
MOVEMENT DISORDERS, 2017, 32
[40] Progressive freezing of gait in atypical parkinsonism: A Possible Progressive Supranuclear Palsy phenotype
Pacheco Mendoza, H.
Nunez Orozco, L.
Negrete Gomez, A.
Delgado Uriarte, J.
Gomez Rubio, C.
MOVEMENT DISORDERS, 2024, 39 : S38 - S38

← 1 2 3 4 5 →