Sequential Administration of Selinexor then CD19 CAR-T Cells Exhibits Enhanced Efficacy in a Mouse Model of Human Non-Hodgkin's Lymphoma

被引:3
|
作者
Stadel, Ryan [1 ]
Liu, Ruifu [2 ]
Landesman, Yosef [3 ]
Wald, David [1 ,2 ]
Vasanna, Smitha Hosahalli [4 ]
de Lima, Marcos J. G. [5 ]
机构
[1] CuronBiotech Inc, Cleveland, OH USA
[2] Case Western Reserve Univ, Cleveland, OH 44106 USA
[3] Karyopharm Therapeut Inc, Newton, MA USA
[4] Rainbow Babies & Childrens Hosp, 2101 Adelbert Rd, Cleveland, OH 44106 USA
[5] Ohio State Univ, Dept Internal Med, Div Hematol, Blood & Marrow & Cellular Therapy Program, Columbus, OH 43210 USA
关键词
D O I
10.1182/blood-2022-164443
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:7413 / 7414
页数:2
相关论文
共 50 条
  • [41] Assessing impacts of tumor burden and CAR-T cell dosage on the toxicity and efficacy profile of CD19 CAR-T therapy in a PBMC-humanized mouse model
    Lee, Won
    Rose, Destanie
    Keck, James G.
    Yang, Jiwon
    CANCER RESEARCH, 2024, 84 (06)
  • [42] CD30-DIRECTED CAR T-CELLS FOR THE TREATMENT OF PEDIATRIC HODGKIN LYMPHOMA AND NON-HODGKIN LYMPHOMA
    Hucks, George
    Savoldo, Barbara
    Dotti, Gianpietro
    Cheng, Catherine
    Laing, Spencer
    Kasow, Kimberly
    Winstead, Michael
    Patel, Arpita
    Presler, Cammie
    Grover, Natalie
    Shea, Thomas
    Riches, Marcie
    Beaven, Anne
    Serody, Jonathan
    PEDIATRIC BLOOD & CANCER, 2020, 67 : S12 - S13
  • [43] Antibody therapy targeting CD19 for B-cell non-Hodgkin's lymphoma
    Makita, S.
    Tobinai, K.
    ANNALS OF ONCOLOGY, 2018, 29 (05) : 1086 - 1089
  • [44] Enhanced efficacy of CD19/CD22 bispecific CAR-T cells with EAAAK linker on B-cell malignancies
    Ma, Renyuxue
    You, Fengtao
    Tian, Shuaiyu
    Zhang, Tingting
    Tian, Xiaopeng
    Xiang, Shufen
    Wu, Hai
    Yang, Nan
    An, Gangli
    Yang, Lin
    EUROPEAN JOURNAL OF HAEMATOLOGY, 2024, 112 (01) : 64 - 74
  • [45] Tandem CD19/CD22 Dual Targets CAR-T Cells Therapy Obtains Superior CR Rate Than Single CD19 CAR-T Cells Infusion As Well As Sequential CD19 and CD22 CAR-T Cells Infusion for Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia Patients
    Liu, Sining
    Zhang, Xinyue
    Dai, Haiping
    Cui, Qingya
    Cui, Wei
    Yin, Jia
    Li, Zheng
    Xue, Shengli
    Yang, Chunxiu
    Yang, Xiao
    Qiu, Huiying
    Miao, Miao
    Chen, Suning
    Jin, Zhengming
    Fu, Chengcheng
    Li, Caixia
    Sun, Aining
    Han, Yue
    Wang, Ying
    Yu, Lei
    Wu, Depei
    Tang, Xiaowen
    BLOOD, 2021, 138
  • [46] Detail Analysis of Non-Specific Activation of CD19 CAR-T Cells Caused by CAR Design
    Okamoto, Sachiko
    Amaishi, Yasunori
    Pei, Zheng
    Mineno, Junichi
    MOLECULAR THERAPY, 2015, 23 : S84 - S85
  • [47] Peripheral eosinophil counts predict efficacy of anti-CD19 CAR-T cell therapy against B-lineage non-Hodgkin lymphoma
    Jia, Q.
    Qin, D.
    He, F.
    Xie, Q.
    Cheng, J. -N.
    Zuo, X.
    Xu, L.
    Fang, H.
    Hu, C.
    Peng, L.
    Jin, T.
    Shi, Z.
    Alexander, P.
    Wang, Y.
    Liu, Y.
    Wang, P.
    Li, Q. -J.
    Zhu, B.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 1724 - 1724
  • [48] Peripheral eosinophil counts predict efficacy of anti-CD19 CAR-T cell therapy against B-lineage non-Hodgkin lymphoma
    Jia, Qingzhu
    Qin, Diyuan
    He, Feng
    Xie, Qichao
    Ying, Zhitao
    Zhang, Yajing
    Song, Yuqin
    Cheng, Jia-Nan
    Zuo, Xuejiao
    Xu, Luxiang
    Fang, Hongliang
    Hu, Chunyan
    Peng, Lina
    Jin, Tao
    Shi, Zixiao
    Alexander, Peter B.
    Wang, Yongsheng
    Liu, Yarong
    Han, Weidong
    Zhu, Jun
    Wang, Pin
    Li, Qi-Jing
    Zhu, Bo
    THERANOSTICS, 2021, 11 (10): : 4699 - 4709
  • [49] Safety and efficacy of a new academic CD19-directed CAR-T cell for refractory/relapsed non-Hodgkin lymphoma and acute lymphoblastic leukemia in Brazil
    Donadel, Camila D.
    De Santis, Gil C.
    Goncalves, Thiago E.
    Pires, Bruno G.
    Palma, Leonardo C.
    Gava, Flavia
    Guerino-Cunha, Renato Luiz
    Faria, Joana T. B.
    Silva, Gabriela V. A.
    Darrigo-Junior, Luiz Guilherme
    Fatobene, Giancarlo
    Rocha, Vanderson
    Covas, Dimas T.
    Calado, Rodrigo T.
    Cle, Diego, V
    BONE MARROW TRANSPLANTATION, 2024, 59 (07) : 1040 - 1042
  • [50] CD19 CAR-T cell treatment of CNS relapse of Burkitt's lymphoma: A case report
    Baur, R.
    Aigner, M.
    Voelkl, S.
    Jacobs, B.
    Gary, R.
    Kretschmann, S.
    Achenbach, S.
    Mackensen, A.
    Mougiakakos, D.
    ONCOLOGY RESEARCH AND TREATMENT, 2020, 43 (SUPPL 4) : 242 - 242