Microsatellite instability in colorectal cancer

被引:7
|
作者
Horvat, Matej [1 ]
Stabuc, Borut [2 ]
机构
[1] Univ Med Ctr Maribor, Maribor, Slovenia
[2] Univ Med Ctr Ljubljana, Dept Gastroenterol, Ljubljana, Slovenia
基金
美国国家卫生研究院;
关键词
colorectal cancer; microsatellite instability; chemotherapy; DNA MISMATCH REPAIR; COLON-CANCER; ADJUVANT CHEMOTHERAPY; GENOMIC INSTABILITY; DRUG-RESISTANCE; 5-FLUOROURACIL; TUMORIGENESIS; PREDICTION; CARCINOMA; EFFICACY;
D O I
10.2478/v10019-011-0005-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background. Colorectal cancer (CRC) is the third most common cancer in the world. In 75% CRC develops sporadically, in 25% hereditary or as a consequence of inflammatory bowel disease. CRC carcinogenesis develops over many years. The cause of CRC in 85% is chromosomal instability (CIN) and in 15% microsatellite instability (MSI-H), where hereditary nonpolyposis colorectal cancer (HNPCC) represents 10-20%. Microsatellite sequences (MS) are repeated sequences of short stretches of DNA all over the genome. Microsatellite stability (MSS) means MS are the same in each cell of an individual, whereas microsatellite instability (MSI-H) means MS differ in normal and cancer cells of an individual. The cause of MSI-H is a damaged mismatch repair mechanism (MMR), with the most important MMR proteins being MSH2, MLH1 and MSH6. Conclusions. MSI-H seems to be an important prognostic factor in CRC and an important predictive factor of CRC chemotherapeutic treatment efficacy. Clinical trials conducted until now have shown contradictory findings in different chemotherapeutic settings, adjuvant and palliative; therefore MSI-H is going to be the object of the future research. The future of cancer treatment is in the individualized therapy based on molecular characteristics of the tumour, such as MSI-H in CRC.
引用
收藏
页码:75 / 81
页数:7
相关论文
共 50 条
  • [41] Microsatellite instability among patients with colorectal cancer
    Montenegro, Yenny
    Ramirez-Castro, Jose Luis
    Isaza, Luis Fernando
    Bedoya, Gabriel
    Muneton-Penia, Carlos Mario
    REVISTA MEDICA DE CHILE, 2006, 134 (10) : 1221 - 1229
  • [42] The clinical utility of microsatellite instability in colorectal cancer
    Diao, Zhenli
    Han, Yanxi
    Chen, Yuqing
    Zhang, Rui
    Li, Jinming
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2021, 157
  • [43] Clinical Relevance of Microsatellite Instability in Colorectal Cancer
    de la Chapelle, Albert
    Hampel, Heather
    JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (20) : 3380 - 3387
  • [44] Mitochondrial microsatellite instability in patients with metastatic colorectal cancer
    S. Venderbosch
    S. van Vliet
    M. H. C. Craenmehr
    F. Simmer
    A. F. J. de Haan
    C. J. A. Punt
    M. Koopman
    I. D. Nagtegaal
    Virchows Archiv, 2015, 466 : 495 - 502
  • [45] Regional reproducibility of microsatellite instability in sporadic colorectal cancer
    Samowitz, WS
    Slattery, ML
    GENES CHROMOSOMES & CANCER, 1999, 26 (02): : 106 - 114
  • [46] Prognostic significance of microsatellite instability in sporadic colorectal cancer
    Seok-Byung Lim
    Seung-Yong Jeong
    Min Ro Lee
    Ja-Lok Ku
    Young-Kyoung Shin
    Woo Ho Kim
    Jae-Gahb Park
    International Journal of Colorectal Disease, 2004, 19 : 533 - 537
  • [47] Validation of morphologic predictors of microsatellite instability in colorectal cancer
    Greenson, J. K.
    Rennert, G.
    Presswala, S.
    Low, M.
    Rozek, L. S.
    Bonner, J. D.
    Thomsho, L. P.
    Gruber, S. B.
    MODERN PATHOLOGY, 2007, 20 : 116A - 116A
  • [48] Microsatellite instability and promoter hypermethylation in colorectal cancer in India
    Kanth, V. V. Ravi
    Bhalsing, Sandeep
    Sasikala, M.
    Rao, G. V.
    Pradeep, R.
    Avanthi, Urmila Steffie
    Reddy, D. Nageshwar
    TUMOR BIOLOGY, 2014, 35 (05) : 4347 - 4355
  • [49] Clinicopathologic features in colorectal cancer patients with microsatellite instability
    Raut, CP
    Pawlik, TM
    Rodriguez-Bigas, MA
    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2004, 568 (02) : 275 - 282
  • [50] The prognostic role of microsatellite instability in colorectal cancer patients
    Micu, Bogdan V.
    Andercou, Octavian
    Vesa, Stefan C.
    Micu, Carmen M.
    Pop, Tudor R.
    Constantea, Nicolae
    ANNALI ITALIANI DI CHIRURGIA, 2017, 88 (05) : 425 - 432