Serum Endocan Levels Are Correlated with the Presence and Severity of Coronary Artery Disease in Patients with Hypertension

被引：59
|
作者：
Wang, Xiang-sheng [1 ]
Yang, Wen [3 ]
Luo, Tong [1 ]
Wang, Jian-ming [2 ]
Jing, Yan-yan [4 ]
机构：
[1] Chinese Med Hosp Jining, Dept Internal Med, Jining, Peoples R China
[2] Chinese Med Hosp Jining, Dept Cardiovasc Med, Jining, Peoples R China
[3] Qingdao Univ, Affiliated Yuhuangding Hosp, Dept Nephrol, Yantai 264000, Peoples R China
[4] Qingdao Univ, Affiliated Yuhuangding Hosp, Dept Cardiol, Yantai 264000, Peoples R China
来源：
GENETIC TESTING AND MOLECULAR BIOMARKERS | 2015年 / 19卷 / 03期
关键词：
CELL-SPECIFIC MOLECULE-1; ENDOTHELIAL FUNCTION; PSORIASIS; THERAPY; MARKER; ESM-1;
D O I：
10.1089/gtmb.2014.0274
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Background: Endothelial dysfunction is one of the most important early indicators of atherosclerosis in hypertension (HT) patients. Endocan has been reported to play a role in the pathophysiology of endothelial dysfunction. Objective: We sought to assess whether serum endocan levels are correlated with the presence and severity of coronary artery disease (CAD) in patients with HT. Methods: We measured endocan levels in 164 patients with HT and in 55 controls. The severity of CAD was assessed by the coronary atherosclerosis index scores. Results: Serum endocan levels were independently correlated with the presence and severity of CAD in HT patients. Conclusion: Endocan might function as a useful biomarker for monitoring the development and progression of CAD in HT patients.
引用
收藏
页码：124 / 127
页数：4
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