Isolation of macrocarpene-type sesquiterpenes from stigma maydis with neuroprotective activities

被引：18
|
作者：
Zhou, Wei-Yu [1 ]
Lin, Bin [2 ]
Hou, Zi-Lin [1 ]
Shi, Shao-Chun [1 ]
Wang, Yu-Xi [1 ]
Huang, Xiao-Xiao [1 ]
Song, Shao-Jiang [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Computat Chem Based Nat Antitumor Drug Re, Shenyang 110016, Liaoning, Peoples R China
[2] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China
来源：
FITOTERAPIA | 2020年 / 141卷
关键词：
Stigma maydis; Sesquiterpenes; NMR calculations; DP4+; Calculated ECD; Neuroprotective activities; CORN SILK; ZEA-MAYS; POLYSACCHARIDES;
D O I：
10.1016/j.fitote.2019.104448
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Five undescribed macrocarpene-type sesquiterpenes (1-5), along with a known analogue (6) were isolated from the crude extract of stigma maydis. The structures of these compounds were elucidated based on comprehensive spectroscopic analyses together with quantum chemical calculations of C-13 NMR data and electronic circular dichroism (ECD) curves. All isolated compounds were tested for their neuroprotective effects against the injury of human neuroblastoma SH-SY5Y cells induced by H2O2. Among them, compounds 3 (65.89%) and 5 (64.38%) showed moderate neuroprotective activity at 50 mu M.
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页数：6
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