Isolation of macrocarpene-type sesquiterpenes from stigma maydis with neuroprotective activities

被引：18

作者：

Zhou, Wei-Yu ^{[1
]}

Lin, Bin ^{[2
]}

Hou, Zi-Lin ^{[1
]}

Shi, Shao-Chun ^{[1
]}

Wang, Yu-Xi ^{[1
]}

Huang, Xiao-Xiao ^{[1
]}

Song, Shao-Jiang ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Computat Chem Based Nat Antitumor Drug Re, Shenyang 110016, Liaoning, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China

来源：

FITOTERAPIA | 2020年 / 141卷

关键词：

Stigma maydis; Sesquiterpenes; NMR calculations; DP4+; Calculated ECD; Neuroprotective activities; CORN SILK; ZEA-MAYS; POLYSACCHARIDES;

D O I：

10.1016/j.fitote.2019.104448

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five undescribed macrocarpene-type sesquiterpenes (1-5), along with a known analogue (6) were isolated from the crude extract of stigma maydis. The structures of these compounds were elucidated based on comprehensive spectroscopic analyses together with quantum chemical calculations of C-13 NMR data and electronic circular dichroism (ECD) curves. All isolated compounds were tested for their neuroprotective effects against the injury of human neuroblastoma SH-SY5Y cells induced by H2O2. Among them, compounds 3 (65.89%) and 5 (64.38%) showed moderate neuroprotective activity at 50 mu M.

引用

页数：6

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