Ameliorating effect of Gardenia jasminoides extract on amyloid beta peptide-induced neuronal cell deficit

被引：0
|
作者：
Choi, Soo Jung
Kim, Mi-Jeong
He, Ho Jin
Hong, Bumshik
Cho, Hong Yon
Kim, Young Jun
Kim, Hye Kyung
Lim, Seung-Taik
Jun, Woo Jin
Kim, Eun-Ki
Shin, Dong-Hoon [1 ]
机构：
[1] Korea Univ, Dept Food & Biotechnol, Seoul 136701, South Korea
[2] Korea Univ, Dept Food Technol, Seoul 136701, South Korea
[3] Gyeongsang Natl Univ, Dept Food Sci & Technol, Jinju 660701, Gyeongnam, South Korea
[4] Gyeongsang Natl Univ, Inst Agr & Life Sci, Jinju 660701, Gyeongnam, South Korea
[5] Hanseo Univ, Dept Food & Biotechnol, Seosan 356820, South Korea
[6] Chonnam Natl Univ, Dept Food & Nutr, Kwangju 500757, South Korea
[7] Inha Univ, Dept Biol Engn, Inchon 402751, South Korea
来源：
MOLECULES AND CELLS | 2007年 / 24卷 / 01期
关键词：
Alzheimer's disease; amyloid beta; gardenia jasminoides; oxidative stress; PC; 12; cells;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The brains of Alzheimer's disease (AD) patients are characterized by large deposits of amyloid beta peptide (A beta). A beta is known to increase free radical production in nerve cells, leading to cell death that is characterized by lipid peroxidation, free radical formation, protein oxidation, and DNA/RNA oxidation. In this study, we selected an extract of Gardenia jasminoides by screening, and investigated its ameliorating effects on A beta-induced oxidative stress using PC12 cells. The effects of the extract were evaluated using the 2',7'-dichlorofluorescein diacetate (DCF-DA) assay and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction assay. To find the active component, the ethanol extract was partitioned with hexane, chloroform, and ethyl acetate, respectively, and the active component was purified by silica-gel column chromatography and HPLC. The results suggested that Gardenia-jasminoides extract can reduce the cytotoxicity of A beta in PC 12 cells, possibly by reducing oxidative stress.
引用
收藏
页码：113 / 118
页数：6
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