Difunctionalization of gem-Difluoroalkenes via Photoredox Catalysis: Synthesis of Diverse α,α-Difluoromethyl-β-alkoxysulfones

被引：19
|
作者：
Zhu, Wenjuan [1 ,2 ]
Xi, Hui [3 ]
Jiao, Wenyang [1 ,2 ]
Huang, Lihua [1 ,2 ]
Wang, Lianjie [1 ,2 ]
Wu, Junliang [1 ,2 ]
机构：
[1] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China
[2] Zhengzhou Univ, Inst Green Catalysis, Zhengzhou 450001, Peoples R China
[3] China Natl Tobacco Co, Zhengzhou Tobacco Res Inst, Zhengzhou 450001, Peoples R China
来源：
ORGANIC LETTERS | 2022年 / 24卷 / 02期
关键词：
STEREOSELECTIVE-SYNTHESIS; ALKENES; ACIDS; DIFLUOROMETHYLATION; ALKYLATION; ACTIVATION; SECONDARY; FLUORINE; TERTIARY; ALKYNES;
D O I：
10.1021/acs.orglett.1c04165
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Visible-light-promoted alkoxysulfonylation of gem-difluoroalkenes using sulfonyl chlorides and alcohols has been developed. The reaction exhibits a relatively broad substrate scope with excellent functional group compatibility. This synthesis method includes an atom transfer radical addition-like process. The products can be used as platform molecules for further modification.
引用
收藏
页码：720 / 725
页数：6
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