Urumamide, a novel chymotrypsin inhibitor with a β-amino acid from a marine cyanobacterium Okeania sp.

被引：13
|
作者：
Kanamori, Yuki [1 ]
Iwasaki, Arihiro [1 ]
Sumimoto, Shinpei [1 ]
Suenaga, Kiyotake [1 ]
机构：
[1] Keio Univ, Dept Chem, Kohoku Ku, 3-14-1 Hiyoshi, Yokohama, Kanagawa 2238522, Japan
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 37期
关键词：
Urumamide; Marine cyanobacteria; Depsipeptide; beta-Amino acid; Okeania; POTENT ELASTASE INHIBITORS; LYNGBYA-MAJUSCULA; CYCLIC DEPSIPEPTIDE; BIOLOGICAL-ACTIVITY; DOLASTATIN-13; ASSEMBLAGE;
D O I：
10.1016/j.tetlet.2016.08.012
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Urumamide, a novel cyclic depsipeptide that contains a beta-amino acid, was isolated from a marine cyanobacterium Okeania sp. Its gross structure was determined by spectroscopic analyses, and the absolute configuration was established based on Marfey's analyses and chiral HPLC analyses of hydrolysis products. Biologically, urumamide inhibited the growth of human cancer cells. In addition, urumamide inhibited chymotrypsin. (C) 2016 Published by Elsevier Ltd.
引用
收藏
页码：4213 / 4216
页数：4
相关论文
共 50 条
  • [41] Biselyngbyolide B, a Novel ER Stress-inducer Isolated from the Marine Cyanobacterium Lyngbya sp.
    Ohno, Osamu
    Watanabe, Ayane
    Morita, Maho
    Suenaga, Kiyotake
    CHEMISTRY LETTERS, 2014, 43 (03) : 287 - 289
  • [42] Nostocyclyne A, a novel antimicrobial cyclophane from the cyanobacterium Nostoc sp.
    Ploutno, A
    Carmeli, S
    JOURNAL OF NATURAL PRODUCTS, 2000, 63 (11): : 1524 - 1526
  • [43] A novel α-amylase from the cyanobacterium Nostoc sp. PCC 7119
    Francisco M. Reyes-Sosa
    Fernando P. Molina-Heredia
    Miguel A. De la Rosa
    Applied Microbiology and Biotechnology, 2010, 86 : 131 - 141
  • [44] Three novel metabolites from a bloom of the cyanobacterium Microcystis sp.
    Gesner-Apter, Shiri
    Carmeli, Shmuel
    TETRAHEDRON, 2008, 64 (28) : 6628 - 6634
  • [45] Okeanic acid-A, a trihydroxy fatty acid from the Okinawan cyanobacterium Okeania hirsuta
    Nishino, Haruka
    Kanda, Nao
    Zhang, Bo-Tao
    Kamio, Michiya
    Uchida, Hajime
    Sugahara, Kohtaro
    Nagai, Hiroshi
    Satake, Masayuki
    NATURAL PRODUCT RESEARCH, 2024,
  • [46] Janadolide, a Cyclic Polyketide-Peptide Hybrid Possessing a tert-Butyl Group from an Okeania sp Marine Cyanobacterium
    Ogawa, Hidetoshi
    Iwasaki, Arihiro
    Sumimoto, Shinpei
    Kanamori, Yuki
    Ohno, Osamu
    Iwatsuki, Masato
    Ishiyama, Aki
    Hokari, Rei
    Otoguro, Kazuhiko
    Omura, Satoshi
    Suenaga, Kiyotake
    JOURNAL OF NATURAL PRODUCTS, 2016, 79 (07): : 1862 - 1866
  • [47] Wajeepeptin, a Cytotoxic and Antitrypanosomal Cyclic Depsipeptide from a Marine Moorena sp. Cyanobacterium
    Kurisawa, Naoaki
    Jeelani, Ghulam
    Nozaki, Tomoyoshi
    Agusta, Adnan Luthfi
    Suenaga, Kiyotake
    Iwasaki, Arihiro
    JOURNAL OF NATURAL PRODUCTS, 2024, 87 (07): : 1838 - 1843
  • [48] Jahanyne, an Apoptosis-Inducing Lipopeptide from the Marine Cyanobacterium Lyngbya sp.
    Iwasaki, Arihiro
    Ohno, Osamu
    Sumimoto, Shinpei
    Ogawa, Hidetoshi
    Kim Anh Nguyen
    Suenaga, Kiyotake
    ORGANIC LETTERS, 2015, 17 (03) : 652 - 655
  • [49] Ulongapeptin, a cytotoxic cyclic depsipeptide from a Palauan marine cyanobacterium Lyngbya sp.
    Williams, PG
    Yoshida, WY
    Quon, MK
    Moore, RE
    Paul, VJ
    JOURNAL OF NATURAL PRODUCTS, 2003, 66 (05): : 651 - 654
  • [50] Mitsoamide:: A cytotoxic linear lipopeptide from the Madagascar marine cyanobacterium Geitlerinema sp.
    Andrianasolo, Eric H.
    Goeger, Douglas
    Gerwick, William H.
    PURE AND APPLIED CHEMISTRY, 2007, 79 (04) : 593 - 602
12345