Urumamide, a novel chymotrypsin inhibitor with a β-amino acid from a marine cyanobacterium Okeania sp.

被引：13

作者：

Kanamori, Yuki ^{[1
]}

Iwasaki, Arihiro ^{[1
]}

Sumimoto, Shinpei ^{[1
]}

Suenaga, Kiyotake ^{[1
]}

机构：

[1] Keio Univ, Dept Chem, Kohoku Ku, 3-14-1 Hiyoshi, Yokohama, Kanagawa 2238522, Japan

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 37期

关键词：

Urumamide; Marine cyanobacteria; Depsipeptide; beta-Amino acid; Okeania; POTENT ELASTASE INHIBITORS; LYNGBYA-MAJUSCULA; CYCLIC DEPSIPEPTIDE; BIOLOGICAL-ACTIVITY; DOLASTATIN-13; ASSEMBLAGE;

D O I：

10.1016/j.tetlet.2016.08.012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Urumamide, a novel cyclic depsipeptide that contains a beta-amino acid, was isolated from a marine cyanobacterium Okeania sp. Its gross structure was determined by spectroscopic analyses, and the absolute configuration was established based on Marfey's analyses and chiral HPLC analyses of hydrolysis products. Biologically, urumamide inhibited the growth of human cancer cells. In addition, urumamide inhibited chymotrypsin. (C) 2016 Published by Elsevier Ltd.

引用

页码：4213 / 4216

页数：4

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