CYP2A6 gene polymorphism and personality traits for NEO-FFI on the smoking behavior of youths

被引：7
|
作者：
Waga, Chikako
Iwahashi, Kazuhiko
机构：
[1] Azabu Univ, Hlth Adm Ctr, Dept Neurophysiol, Sagamihara, Kanagawa, Japan
[2] Grad Sch Environm Hlth, Dept Neurol, Kanagawa, Japan
来源：
DRUG AND CHEMICAL TOXICOLOGY | 2007年 / 30卷 / 04期
关键词：
CYP2A6; nicotine dependence; openness; NICOTINE METABOLISM; VARIANT;
D O I：
10.1080/01480540701522338
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We performed a survey on the relationship between nicotine dependence and psychological (the personality traits using neuroticism extroversion openess-five factor inventory (NEO-FFI)/nicotine metabolism (the CYP2A6 gene polymorphism) factors among Japanese young students to elucidate the mechanism of the development of nicotine dependence. As a result, the frequency of the CYP2A6*4C gene (enzyme activity deficit) was significantly (p < 0.05) higher among nonsmokers than smokers, and the Openness score by NEO-FFI was higher among smokers than nonsmokers. However, there were no significant differences in the Neuroticism, Extraversion, Agreeableness, and Conscientiousness scores by NEO-FFI between smokers and nonsmokers. We conclude that the CYP2A6*4C gene and the Openness personality trait may affect the development of the smoking behavior of youth.
引用
收藏
页码：343 / 349
页数：7
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