Targeting adipokines: A new strategy for the treatment of myocardial fibrosis

被引：8

作者：

Han, Xiaoying ^{[1
]}

Zhang, Yi ^{[1
]}

Zhang, Xinyu ^{[1
]}

Ji, Haixia ^{[1
]}

Wang, Wenzhe ^{[1
]}

Qiao, Ou ^{[1
]}

Li, Xia ^{[1
]}

Wang, Juan ^{[1
]}

Liu, Changxiao ^{[2
]}

Huang, Luqi ^{[3
]}

Gao, Wenyuan ^{[1
]}

机构：

[1] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China

[2] Tianjin Pharmaceut Res Inst, Tianjin 300072, Peoples R China

[3] Chinese Acad Chinese Med Sci, Natl Resource Ctr Chinese Mat Med, Beijing, Peoples R China

来源：

PHARMACOLOGICAL RESEARCH | 2022年 / 181卷

关键词：

Adipokines; Cardiac fibrosis; Cardiovascular dysfunction; Angiotensin system; Strategies; EPICARDIAL ADIPOSE-TISSUE; GROWTH-FACTOR-BETA; ENDOPLASMIC-RETICULUM STRESS; HIGH-FAT DIET; ANGIOTENSIN-II; CARDIAC FIBROBLASTS; T-CADHERIN; PPAR-DELTA; ADIPONECTIN RECEPTORS; OMENTIN;

D O I：

10.1016/j.phrs.2022.106257

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cardiac fibrosis is a pathogenic factor of many cardiovascular diseases (CVD), which seriously affects people's life and health, causing huge economic losses.Therefore, it is very significant to find an effective treatment for myocardial fibrosis. Adipokines are mainly derived from adipose tissue and have an prominent regulatory effect on glucose and lipid metabolism, inflammation, immune response and cardiovascular function. Adipose tissue is composed of a variety of cell types, including adipocytes, endothelial cells, macrophages and smooth muscle cells. Adipokines mainly include adiponectin, leptin, resistin, visfatin and omentin, which are synthesized and secreted by adipocytes. More and more evidence shows that adipokines can regulate the progress of cardiac fibrosis. This scientific review provides new ideas for targeting adipokines in the treatment of myocardial fibrosis and provides strategies for the development of new, safe, and effective pharmacological antagonists against myocardial fibrosis based on adipokines activity.

引用

页数：10

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