Chemical Constituents from Walsura pinnata (Meliaceae)

被引：0

作者：

Mandzir, Mohamad A. ^{[1
]}

Shilpi, Jamil A. ^{[2
]}

Mahmud, Norfaizah ^{[3
]}

Ramasamy, Sujatha ^{[3
]}

Awang, Khalijah ^{[1
]}

机构：

[1] Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur 50603, Malaysia

[2] Khulna Univ, Life Sci Sch, Pharm Discipline, Khulna 9208, Bangladesh

[3] Univ Malaya, Fac Sci, Inst Biol Sci, Kuala Lumpur 50603, Malaysia

来源：

NATURAL PRODUCT COMMUNICATIONS | 2017年 / 12卷 / 09期

关键词：

Walsztra pinnata; Cytotoxicity; NRU assay; Terpenoids; Glutinane; Oleanane; TRITERPENES; TRICHOSTEMON; TIRUCALLANE; TERPENOIDS; LIMONOIDS; ALKALOIDS; SKELETON; LEAVES;

D O I：

10.1177/1934578X1701200905

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A phytochemical study on the bark of Walsura pinnata has led to the isolation of a new oleanane triterpene acid, 3-oxo-olean-9(11),12-dien-28-oic acid (1), together with nine known compounds (2-10). Their structures were established on the basis of the detailed spectroscopic analysis, including one- and two-dimensional NMR, ESI-MS and HR-ESI-MS techniques. Compounds 2, 3, 5, 6 and 8 were isolated from W. pinnata for the first time. Compounds 3 and 4 showed in vitro growth inhibitory activity against two human cancer cell lines MCF-7 and SK-OV-3 with IC50 values within the range of 8.85 - 18.28 mu g/mL. To the best of our knowledge, this is the first report on the cytotoxic activity of compound 3 towards both cancer cell lines.

引用

页码：1397 / 1400

页数：4

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