Chemical Constituents from Walsura pinnata (Meliaceae)

被引：0
|
作者：
Mandzir, Mohamad A. [1 ]
Shilpi, Jamil A. [2 ]
Mahmud, Norfaizah [3 ]
Ramasamy, Sujatha [3 ]
Awang, Khalijah [1 ]
机构：
[1] Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur 50603, Malaysia
[2] Khulna Univ, Life Sci Sch, Pharm Discipline, Khulna 9208, Bangladesh
[3] Univ Malaya, Fac Sci, Inst Biol Sci, Kuala Lumpur 50603, Malaysia
来源：
NATURAL PRODUCT COMMUNICATIONS | 2017年 / 12卷 / 09期
关键词：
Walsztra pinnata; Cytotoxicity; NRU assay; Terpenoids; Glutinane; Oleanane; TRITERPENES; TRICHOSTEMON; TIRUCALLANE; TERPENOIDS; LIMONOIDS; ALKALOIDS; SKELETON; LEAVES;
D O I：
10.1177/1934578X1701200905
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A phytochemical study on the bark of Walsura pinnata has led to the isolation of a new oleanane triterpene acid, 3-oxo-olean-9(11),12-dien-28-oic acid (1), together with nine known compounds (2-10). Their structures were established on the basis of the detailed spectroscopic analysis, including one- and two-dimensional NMR, ESI-MS and HR-ESI-MS techniques. Compounds 2, 3, 5, 6 and 8 were isolated from W. pinnata for the first time. Compounds 3 and 4 showed in vitro growth inhibitory activity against two human cancer cell lines MCF-7 and SK-OV-3 with IC50 values within the range of 8.85 - 18.28 mu g/mL. To the best of our knowledge, this is the first report on the cytotoxic activity of compound 3 towards both cancer cell lines.
引用
收藏
页码：1397 / 1400
页数：4
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