Type 3 IP3 receptors driving oncogenesis

被引：14
|
作者：
Sneyers, Flore
Rosa, Nicolas
Bultynck, Geert [1 ,2 ]
机构：
[1] Katholieke Univ Leuven, Lab Mol & Cellular Signaling, Dept Cellular & Mol Med, Campus Gasthuisberg O-N-I,Bus 802,Herestr 49, BE-3000 Leuven, Belgium
[2] Leuven Kanker Inst, Campus Gasthuisberg O-N-I,Bus 802,Herestr 49, BE-3000 Leuven, Belgium
来源：
CELL CALCIUM | 2020年 / 86卷
关键词：
ITPR3; IP3R3; channels; Calcium signaling; Cancer; Oncogenesis; MITOCHONDRIAL CALCIUM UNIPORTER; CANCER;
D O I：
10.1016/j.ceca.2019.102141
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Type 3 Inositol 1,4,5-trisphosphate (IP3) receptors (IP(3)R3s) have been identified as anti-oncogenic channels by propelling pro-apoptotic Ca2+ signals to mitochondria. Yet, recent studies (Rezuchova et al, Cell Death Dis, 2019; Ueasilamongkol et al, Hepathology, 2019; Guerra et al, Gut, 2019) revealed that IP(3)R3 upregulation drives oncogenesis via ER-mitochondrial Ca2+ crosstalk, adding complexity to IP(3)R3's role in cancer.
引用
收藏
页数：3
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