Liquid Biopsy in Non-Small Cell Lung Cancer

被引：48

作者：

Molina-Vila, Miguel A. ^{[1
]}

Mayo-de-las-Casas, Clara ^{[1
]}

Gimenez-Capitan, Ana ^{[1
]}

Jordana-Ariza, Nuria ^{[1
]}

Garzon, Monica ^{[1
]}

Balada, Ariadna ^{[1
]}

Villatoro, Sergi ^{[1
]}

Teixido, Cristina ^{[1
]}

Garcia-Pelaez, Beatriz ^{[1
]}

Aguado, Cristina ^{[1
]}

Jose Catalan, Maria ^{[1
]}

Campos, Raquel ^{[1
]}

Perez-Rosado, Ana ^{[1
]}

Bertran-Alamillo, Jordi ^{[1
]}

Martinez-Bueno, Alejandro ^{[2
]}

Gil, Maria-de-los-Lianos ^{[2
]}

Gonzalez-Cao, Maria ^{[2
]}

Gonzalez, Xavier ^{[2
]}

Morales-Espinosa, Daniela ^{[2
]}

Viteri, Santiago ^{[2
]}

Karachaliou, Niki ^{[2
]}

Rosell, Rafael ^{[2
,3
]}

机构：

[1] Quiron Dexeus Univ Hosp, Pangaea Biotech, Lab Oncol, Barcelona, Spain

[2] Quiron Dexeus Univ Hosp, Inst Oncol Dr Rosell, Barcelona, Spain

[3] Germans Trias & Pujol Hlth Sci Inst & Hosp, Catalan Inst Oncol, Canc Biol & Precis Med Program, Badalona, Spain

来源：

FRONTIERS IN MEDICINE | 2016年 / 3卷

关键词：

ctDNA; ctRNA; CTCs; exosomes; tumor-educated platelets; mutations; gene fusions; lung cancer; CIRCULATING TUMOR-CELLS; FACTOR RECEPTOR MUTATIONS; FREE DNA; EGFR MUTATIONS; MESSENGER-RNA; CLINICAL-SIGNIFICANCE; DIAGNOSTIC-ACCURACY; PROGNOSTIC-FACTOR; BLOOD-PLATELETS; NSCLC PATIENTS;

D O I：

10.3389/fmed.2016.00069

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Liquid biopsy analyses are already incorporated in the routine clinical practice in many hospitals and oncology departments worldwide, improving the selection of treatments and monitoring of lung cancer patients. Although they have not yet reached its full potential, liquid biopsy-based tests will soon be as widespread as "standard" biopsies and imaging techniques, offering invaluable diagnostic, prognostic, and predictive information. This review summarizes the techniques available for the isolation and analysis of circulating free DNA and RNA, exosomes, tumor-educated platelets, and circulating tumor cells from the blood of cancer patients, presents the methodological challenges associated with each of these materials, and discusses the clinical applications of liquid biopsy testing in lung cancer.

引用

页数：8

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