Characteristic Profiles of Inflammatory Cytokines in the Aqueous Humor of Glaucomatous Eyes

被引：57

作者：

Kokubun, Taiki ^{[1
]}

Tsuda, Satoru ^{[1
]}

Kunikata, Hiroshi ^{[1
,2
]}

Yasuda, Masayuki ^{[1
]}

Himori, Noriko ^{[1
]}

Kunimatsu-Sanuki, Shiho ^{[1
]}

Maruyama, Kazuichi ^{[1
]}

Nakazawa, Toru ^{[1
,2
,3
]}

机构：

[1] Tohoku Univ, Dept Ophthalmol, Grad Sch Med, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi 9808574, Japan

[2] Tohoku Univ, Dept Retinal Dis Control, Ophthalmol, Grad Sch Med, Sendai, Miyagi, Japan

[3] Tohoku Univ, Dept Adv Ophthalm Med, Grad Sch Med, Sendai, Miyagi, Japan

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2018年 / 26卷 / 08期

关键词：

Aqueous humor; cytokine; glaucoma; NVG; POAG; OPEN-ANGLE GLAUCOMA; HUMAN TRABECULAR MESHWORK; MULTIPLE PROINFLAMMATORY CYTOKINES; MONOCYTE CHEMOATTRACTANT PROTEIN-1; ENDOTHELIAL GROWTH-FACTOR; NF-KAPPA-B; EXPRESSION PROFILE; MESSENGER-RNA; CELLS; INTERLEUKIN-8;

D O I：

10.1080/09273948.2017.1327605

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To analyze cytokine profiles of the aqueous humor of eyes with primary open-angle glaucoma (POAG), neovascular glaucoma (NVG), and cataract (as controls). Methods: A multiplex bead assay was used to measure concentrations of 27 cytokines in aqueous humor samples from 54 eyes. Results: Detection rates were as follows: IL-7: NVG higher than POAG; IL-10: POAG lower than cataract or NVG; and GM-CSF: cataract higher than POAG or NVG. Concentrations were as follows: IL-8, IP-10, MCP-1, and MIP-1 beta: POAG and NVG higher than cataract; IL-9: POAG lower than NVG; IL-12: POAG lower than cataract or NVG; and VEGF: NVG higher than cataract or POAG and POAG lower than cataract. Further analysis showed that IL-8, IP-10, MCP-1, and MIP-1 beta were correlated with intraocular pressure and age. Conclusions: The detection rates and levels of various cytokines had different patterns in POAG and NVG patients, suggesting distinctive alterations in the microenvironment in different types of glaucoma.

引用

页码：1177 / 1188

页数：12

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