Host parameters and mode of infection influence outcome in SARS-CoV-2-infected hamsters

被引：12

作者：

Griffin, Bryan D. ^{[1
]}

Warner, Bryce M. ^{[1
,2
]}

Chan, Mable ^{[1
]}

Valcourt, Emelissa ^{[1
]}

Tailor, Nikesh ^{[1
]}

Banadyga, Logan ^{[1
]}

Leung, Anders ^{[1
]}

He, Shihua ^{[1
]}

Boese, Amrit S. ^{[1
]}

Audet, Jonathan ^{[1
]}

Cao, Wenguang ^{[1
]}

Moffat, Estella ^{[3
]}

Garnett, Lauren ^{[1
,2
]}

Tierney, Kevin ^{[1
]}

Tran, Kaylie N. ^{[1
]}

Albietz, Alixandra ^{[1
]}

Manguiat, Kathy ^{[1
]}

Soule, Geoff ^{[1
]}

Bello, Alexander ^{[1
]}

Vendramelli, Robert ^{[1
]}

Lin, Jessica ^{[1
]}

Deschambault, Yvon ^{[1
]}

Zhu, Wenjun ^{[1
]}

Wood, Heidi ^{[1
]}

Mubareka, Samira ^{[4
,5
]}

Safronetz, David ^{[1
,2
]}

Strong, James E. ^{[1
,2
,6
]}

Embury-Hyatt, Carissa ^{[3
]}

Kobasa, Darwyn ^{[1
,2
]}

机构：

[1] Publ Hlth Agcy Canada, Natl Microbiol Lab, Zoonot Dis & Special Pathogens Div, 1015 Arlington St, Winnipeg, MB R3E 3R2, Canada

[2] Univ Manitoba, Coll Med, Fac Hlth Sci, Dept Med Microbiol & Infect Dis, 745 Bannatyne Ave, Winnipeg, MB R3E 0J9, Canada

[3] Canadian Food Inspect Agcy, Natl Ctr Foreign Anim Dis, 1015 Arlington St, Winnipeg, MB R3E 3M4, Canada

[4] Univ Toronto, Fac Med, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A1, Canada

[5] Sunnybrook Res Inst, Biol Sci, Toronto, ON M4N 3M5, Canada

[6] Univ Manitoba, Coll Med, Fac Hlth Sci, Pediat & Child Hlth, 745 Bannatyne Ave, Winnipeg, MB R3E 0J9, Canada

来源：

ISCIENCE | 2021年 / 24卷 / 12期

关键词：

TRANSMISSION;

D O I：

10.1016/j.isci.2021.103530

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The golden hamster model of SARS-CoV-2 infection recapitulates key characteristics of COVID-19. In this work we examined the influence of the route of exposure, sex, and age on SARS-CoV-2 pathogenesis in hamsters. We report that delivery of SARS-CoV-2 by a low- versus high-volume intranasal or intragastric route results in comparable viral titers in the lung and viral shedding. However, low-volume intranasal exposure results in milder weight loss, whereas intragastric exposure leads to a diminished capacity to regain body weight. Male hamsters, and particularly older male hamsters, display an impaired capacity to recover from illness and delayed viral clearance. These factors were found to influence the nature of the host inflammatory cytokine response but had a minimal react on the quality and durability of the humoral immune response and susceptibility to re-infection. These data further elucidate key factors that impact pre-clinical challenge studies carried out in the hamster model of COVID-19.

引用

页数：22

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