Anti-acetylcholine receptor antibodies: effect of immunosuppressive drug therapy in patients with myasthenia gravis

被引：0
|
作者：
Sidnev, D. V. [1 ]
Sanadze, A. G. [1 ]
Dedaev, S. I. [1 ]
Karganov, M. Yu. [1 ]
Alchinova, I. B. [1 ]
机构：
[1] Moscow Myasthen Ctr, Moscow, Russia
来源：
ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA | 2010年 / 110卷 / 11期
关键词：
myasthenia gravis; anti-acetylcholine receptor antibody; immunosuppressive treatment; thymectomy; ACETYLCHOLINE-RECEPTOR; THYMECTOMY; AUTOANTIBODIES; TE671;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We studied anti-acetylcholine receptor antibodies (ARAb) in 25 patients with myasthenia gravis before and after the immunosuppressive drug (steroid) therapy and in 22 patients before and after thymectomy. The clinical effect after the treatment was correlated with the reduction of ARAb levels by more than 20% in 62% of patients. The ARAb levels did not change, or even increased, in 15% patients despite the improvement of their clinical state. We showed the direct correlation between the clinical improvement and the decrease of ARAb level.
引用
收藏
页码：37 / 40
页数：4
相关论文
共 50 条
  • [21] MYASTHENIA-GRAVIS, THYMECTOMY, AND ANTI-ACETYLCHOLINE RECEPTOR ANTIBODY
    BARTOCCIONI, E
    SCUDERI, F
    SCOPPETTA, C
    EVOLI, A
    TONALI, P
    GUIDI, L
    BARTOLONI, C
    TERRANOVA, T
    JOURNAL OF NEUROLOGY, 1980, 224 (01) : 9 - 15
  • [22] ANTI-ACETYLCHOLINE RECEPTOR IGG IN NEONATAL MYASTHENIA-GRAVIS
    NAKAO, K
    NISHITANI, H
    SUZUKI, M
    OHTA, M
    HAYASHI, K
    NEW ENGLAND JOURNAL OF MEDICINE, 1977, 297 (03): : 169 - 169
  • [23] ANTI-ACETYLCHOLINE RECEPTOR ANTIBODY IN JUVENILE MYASTHENIA-GRAVIS
    ONOE, S
    ABE, J
    TAGAWA, T
    ONO, J
    MIMAKI, T
    YABUUCHI, H
    HAYASHI, M
    KIDA, K
    SUGITA, T
    BRAIN & DEVELOPMENT, 1983, 5 (02): : 240 - 240
  • [24] ANTI-ACETYLCHOLINE RECEPTOR ANTIBODY IN NEONATAL MYASTHENIA-GRAVIS
    DONALDSON, JO
    PENN, AS
    LISAK, RP
    ABRAMSKY, O
    BRENNER, T
    SCHOTLAND, DL
    AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1981, 135 (03): : 222 - 226
  • [25] A STUDY OF ANTI-ACETYLCHOLINE RECEPTOR ANTIBODY IN PATIENTS WITH JUVENILE MYASTHENIA-GRAVIS
    MIZUNO, Y
    KAGA, M
    MISHIRO, M
    BRAIN & DEVELOPMENT, 1981, 3 (02): : 236 - 236
  • [26] ANALYSIS OF FALSE NEGATIVE RESULTS IN THE IMMUNOASSAY FOR ANTI-ACETYLCHOLINE RECEPTOR ANTIBODIES IN MYASTHENIA-GRAVIS
    MITTAG, TW
    XU, X
    MOSHOYIANNIS, H
    KORNFELD, P
    GENKINS, G
    CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1984, 31 (02): : 191 - 201
  • [27] PATIENTS WITH MYASTHENIA-GRAVIS AND THYMOMA HAVE ANTI-SKELETAL MUSCLE AND ANTI-ACETYLCHOLINE RECEPTOR ANTIBODIES SIMULTANEOUSLY
    OHTA, M
    OHTA, K
    MORI, F
    HAYASHI, K
    NISHITANI, H
    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 1989, 6 (01) : 65 - 75
  • [28] BINDING-PROPERTIES AND SUBCLASS DISTRIBUTION OF ANTI-ACETYLCHOLINE RECEPTOR ANTIBODIES IN MYASTHENIA-GRAVIS
    LEFVERT, AK
    CUENOUD, S
    FULPIUS, BW
    JOURNAL OF NEUROIMMUNOLOGY, 1981, 1 (01) : 125 - 135
  • [29] An update of the pharmacological treatment options for generalized myasthenia gravis in adults with anti-acetylcholine receptor antibodies
    Riley, Tanya R.
    Douglas, Janine S.
    Wang, Christopher
    Bowser, Kiarra M.
    AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2023, 80 (11) : 652 - 662
  • [30] Efgartigimod for generalized myasthenia gravis with or without anti-acetylcholine receptor antibodies: a worldwide and Japanese perspective
    Suzuki, Shigeaki
    Uzawa, Akiyuki
    Murai, Hiroyuki
    EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2022, 18 (12) : 1207 - 1215
12345