Treatment Outcome of Multidrug-Resistant Mycobacterium tuberculosis in Nepal

被引：8
|
作者：
Kakchapati, Sampurna
Gyawali, Badri Nath [2 ]
Jha, Rakesh Kumar [3 ]
Choonpradub, Chamnein [1 ]
机构：
[1] Prince Songkla Univ, Dept Math & Comp Sci, Fac Sci & Technol, Muang 94000, Thailand
[2] Natl TB Ctr, Kathmandu, Nepal
[3] Wuhan Univ, Wuhan 430072, Peoples R China
来源：
ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH | 2012年 / 24卷 / 04期
关键词：
multidrug-resistant TB; MDR-TB; treatment outcome; sputum smear conversion; culture conversion; Kaplan-Meier curves; Cox proportional hazards; Nepal;
D O I：
10.1177/1010539511408067
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The purpose of this study was to examine factors associated with treatment outcome of multidrug-resistant tuberculosis (MDR-TB) cases in Nepal. A retrospective analysis of MDR-TB cases by demographic determinants and treatment was conducted. A total of 494 MDR-TB cases were registered from 2005 to 2008, with data obtained from the National Tuberculosis Center. Chi-squared tests were used to assess statistically the association between smear and culture conversion and treatment outcome. Determinants were analyzed with the use of Kaplan Meier curves and Cox proportional hazards models to generate estimates of the associations with the time to treatment outcome. Sputum conversion status and culture conversion status were positively associated with treatment outcome for MDR-TB. In a multiple Cox proportional hazards regression model, no determinants were found to be associated with time to cure.
引用
收藏
页码：631 / 640
页数：10
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