The genetic variation of the human HMGB1 gene

被引：37
|
作者：
Kornblit, B.
Munthe-Fog, L.
Petersen, S. L.
Madsen, H. O.
Vindelov, L.
Garred, P.
机构：
[1] Rigshosp, Dept Clin Immunol, Tissue Typing Lab, DK-2100 Copenhagen, Denmark
[2] Univ Copenhagen, Rigshosp, Dept Haematol, Allogene Hematopoiet Cell Transplantat Lab, Copenhagen, Denmark
来源：
TISSUE ANTIGENS | 2007年 / 70卷 / 02期
关键词：
cytokines; HMGB1; inflammation; innate immunity; polymorphisms;
D O I：
10.1111/j.1399-0039.2007.00854.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
High-mobility group box 1 protein (HMGB1) is a nuclear DNA-binding protein, which also functions as a pleiotropic cytokine, implicated in the pathology of several different immune-mediated diseases. The purpose of this study was to examine the HMGB1 gene for putative polymorphisms in 103 healthy Caucasian Danish blood donors. A total of six polymorphisms and four mutations were identified in the HMGB1 gene. Subsequent MatInspector estimation revealed that several polymorphisms might have a potential regulatory impact on HMGB1 transcription. This study has characterized genetic variations in the HMGB1 gene locus, which may have a regulating role in the expression of HMGB1, providing the basis for molecular investigations of the HMGB1 gene in different disease settings.
引用
收藏
页码：151 / 156
页数：6
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