Non-invasive prenatal diagnosis of β-thalassemia by detection of the cell-free fetal DNA in maternal circulation: a systematic review and meta-analysis

被引：18

作者：

Zafari, Mandana ^{[1
]}

Kosaryan, Mehrnoush ^{[1
]}

Gill, Pooria ^{[2
]}

Alipour, Abbass ^{[3
]}

Shiran, Mohammadreza ^{[4
]}

Jalalli, Hossein ^{[1
]}

Banihashemi, Ali ^{[5
]}

Fatahi, Fatemeh ^{[6
]}

机构：

[1] Mazandaran Univ Med Sci, Hemoglobinopathy Inst, Thalassemia Res Ctr, Valiye Asr St, Sari, Mazandaran Prov, Iran

[2] Mazandaran Univ Med Sci, Immunogenet Res Ctr, Sari, Iran

[3] Sch Med, Dept Community Med, Baltimore, MD USA

[4] Mazandaran Univ Med Sci, Sch Med, Dept Physiol & Pharmacol, Sari, Iran

[5] Babol Univ Med Sci, Amir Kola Genet Lab, Sari, Iran

[6] Mazandaran Univ Med Sci, Sari, Iran

来源：

ANNALS OF HEMATOLOGY | 2016年 / 95卷 / 08期

关键词：

Non-invasive prenatal diagnosis; Detection of paternally inherited mutation; Thalassemia; f-DNA; Maternal plasma; FREE NUCLEIC-ACIDS; PLASMA; TOOL; FEASIBILITY; MUTATIONS; KNOWLEDGE; POINT; BLOOD; SERUM; RISK;

D O I：

10.1007/s00277-016-2620-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The discovery of fetal DNA (f-DNA) opens the possibility of early non-invasive procedure for detection of paternally inherited mutation of beta-thalassemia. Since 2002, some studies have examined the sensitivity and specificity of this method for detection of paternally inherited mutation of thalassemia in pregnant women at risk of having affected babies. We conducted a systematic review of published articles that evaluated using this method for early detection of paternally inherited mutation in maternal plasma. A sensitive search of multiple databases was done in which nine studies met our inclusion criteria. The sensitivity and specificity was 99 and 99 %, respectively. The current study found that detection of paternally inherited mutation of thalassemia using analysis of cell-free fetal DNA is highly accurate. This method could replace conventional and invasive methods.

引用

页码：1341 / 1350

页数：10

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