Transgenic Mouse Models and Prion Strains

被引：20
|
作者：
Telling, Glenn C. [1 ,2 ,3 ]
机构：
[1] Univ Kentucky, Med Ctr, Sanders Brown Ctr Aging, Lexington, KY 40506 USA
[2] Univ Kentucky, Med Ctr, Dept Microbiol Immunol & Mol Genet, Lexington, KY 40506 USA
[3] Univ Kentucky, Med Ctr, Dept Neurol, Lexington, KY 40506 USA
来源：
PRION PROTEINS | 2011年 / 305卷
关键词：
Quasi-species; Species barriers; Strains; Transgenic models; CHRONIC WASTING DISEASE; CREUTZFELDT-JAKOB-DISEASE; TRANSMISSIBLE MINK ENCEPHALOPATHY; CERVUS-ELAPHUS-NELSONI; MICE EXPRESSING HUMAN; NATURAL SHEEP SCRAPIE; WHITE-TAILED DEER; SPONGIFORM ENCEPHALOPATHY; VARIANT CJD; EXPERIMENTAL-INFECTION;
D O I：
10.1007/128_2011_166
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Here we review the known strain profiles of various prion diseases of animals and humans, and how transgenic mouse models are being used to elucidate basic molecular mechanisms of prion propagation and strain variation and for assessing the zoonotic potential of various animal prion strains.
引用
收藏
页码：79 / 99
页数：21
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