A facile synthesis of 2, 3-dimethoxy-5-methyl-1, 4-benzoquinones

被引：15
|
作者：
Wang, Jin [2 ]
Yang, Jian [1 ]
Zhou, Rong-Guang [3 ]
Yang, Bo [2 ]
Wu, Yuan-Shuang [2 ]
机构：
[1] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan Province, Peoples R China
[2] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650224, Yunnan Province, Peoples R China
[3] Kunming Pharmaceut Corp, Inst Drug Res & Dev, Kunming 650100, Yunnan Province, Peoples R China
来源：
JOURNAL OF CHEMICAL RESEARCH | 2011年 / 07期
关键词：
coenzyme Q; idebenone; Blanc chloromethylation reaction; Williamson reaction; QUINONES; ANALOGS;
D O I：
10.3184/174751911X13099377293263
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Several 2, 3-dimethoxy-5-methyl-1, 4-benzoquinones substituted at the C-6 position with alkoxy methyl groups were prepared by a reaction sequence starting from 2, 3, 4, 5-tetramethoxytoluene (alkoxy methyl) via a Blanc chloromethylation reaction, Williamson reaction and oxidation. The method provided a good yield of 2, 3-dimethoxy-5-methyl-1, 4-benzoquinones and is suitable for the synthesis of other benzoquinone analogues.
引用
收藏
页码：428 / 430
页数：3
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