A facile synthesis of 2, 3-dimethoxy-5-methyl-1, 4-benzoquinones

被引：15

作者：

Wang, Jin ^{[2
]}

Yang, Jian ^{[1
]}

Zhou, Rong-Guang ^{[3
]}

Yang, Bo ^{[2
]}

Wu, Yuan-Shuang ^{[2
]}

机构：

[1] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan Province, Peoples R China

[2] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650224, Yunnan Province, Peoples R China

[3] Kunming Pharmaceut Corp, Inst Drug Res & Dev, Kunming 650100, Yunnan Province, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2011年 / 07期

关键词：

coenzyme Q; idebenone; Blanc chloromethylation reaction; Williamson reaction; QUINONES; ANALOGS;

D O I：

10.3184/174751911X13099377293263

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several 2, 3-dimethoxy-5-methyl-1, 4-benzoquinones substituted at the C-6 position with alkoxy methyl groups were prepared by a reaction sequence starting from 2, 3, 4, 5-tetramethoxytoluene (alkoxy methyl) via a Blanc chloromethylation reaction, Williamson reaction and oxidation. The method provided a good yield of 2, 3-dimethoxy-5-methyl-1, 4-benzoquinones and is suitable for the synthesis of other benzoquinone analogues.

引用

页码：428 / 430

页数：3

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