Allergen immunotherapy for pediatric asthma: current evidence and knowledge gaps

被引:9
|
作者
Passalacqua, Giovanni [1 ]
Landi, Massimo [2 ,3 ]
Peroni, Diego G. [4 ]
机构
[1] Univ Genoa, IRCCS Policlin San Martino, Dept Internal Med Allergy & Resp Dis, Lgo R Benzi 10, I-16132 Genoa, Italy
[2] Pediat Natl Healthcare Syst, Turin, Italy
[3] Inst Biomed Res & Innovat, Palermo, Italy
[4] Univ Pisa, Dept Expt Med, Pediat, Pisa, Italy
关键词
allergen-specific immunotherapy; allergic asthma; children; efficacy; preventive effects; HOUSE-DUST MITE; GRASS-POLLEN IMMUNOTHERAPY; SUBLINGUAL IMMUNOTHERAPY; DOUBLE-BLIND; CHILDREN; EFFICACY; SAFETY; CHILDHOOD; THERAPY; SENSITIZATION;
D O I
10.1097/ACI.0000000000000618
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Purpose of review The introduction of high-quality and standardized extracts for immunotherapy has renewed the interest in the treatment of pediatric allergic asthma that represents a high-prevalence disease. Recent findings In addition to clinical trials, several systematic reviews and metaanalyses were published, confirming overall the clinical efficacy of allergen immunotherapy in pediatric asthma. In addition, new data on the preventive effect of the treatment on asthma onset were published. Despite this, many intriguing questions emerged, in parallel to the development of knowledge. Allergen immunotherapy is overall effective for the treatment of asthma in children, but a class-effect should not be claimed, rather the efficacy of each single product. According to the recent findings, the challenge for the future research will be to clarify: when to start immunotherapy in children, which are (if they exist) the predictive biomarkers for efficacy in the single individual, the magnitude of the preventive effect and the optimal duration of the treatment.
引用
收藏
页码:162 / 167
页数:6
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