Allergen immunotherapy (AIT) represents at present the unique disease-modifying treatment strategy for IgE-mediated allergic diseases. AIT can induce clinical improvement of allergic asthma, including reduced symptoms, medication use, and improvement of quality of life, with a long-lasting effect after cessation of treatment. Notably, the current asthma guidelines are now recommending sublingual immunotherapy as an add-on therapy for asthma in adults and adolescents with house dust mite allergy. Clinical indications of AIT, with particular reference to pediatric asthma, mechanisms of clinical and immunological tolerance to allergens, and the potential biomarkers predicting clinical response are discussed.
机构:
Wroclaw Med Univ, Dept Clin Immunol, Wroclaw, Poland
ALL MED Med Res Inst, Wroclaw, PolandSTZ Ctr Excellence Asthma, COPD & Resp Allergy Franciscus & Vlietland, Dept Pulmonol, Rotterdam, Netherlands
机构:
Univ Med Rostock, Zentrum Innere Med, Abt Pneumol, Rostock, Germany
Univ Med Rostock, Zentrum Innere Med, Abt Pneumol, Ernst Heydemann Str 6, D-18057 Rostock, GermanyUniv Med Rostock, Zentrum Innere Med, Abt Pneumol, Rostock, Germany