Insulin action and insulin resistance: Diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system

被引：121
|
作者：
Hunter, SJ
Garvey, WT [1 ]
机构：
[1] Med Univ S Carolina, Dept Med, Charleston, SC 29425 USA
[2] Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC USA
来源：
AMERICAN JOURNAL OF MEDICINE | 1998年 / 105卷 / 04期
关键词：
D O I：
10.1016/S0002-9343(98)00300-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Insulin resistance is a primary abnormality in the evolution of type 2 diabetes and is associated with Syndrome X, a cluster of risk factors predisposing to cardiovascular disease. In the polycystic ovary syndrome, insulin resistance may lead to hyperandrogenism; troglitazone, an insulin sensitizer, corrects abnormalities in the pituitary/gonadal axis in these patients.
引用
收藏
页码：331 / 345
页数：15
相关论文
共 50 条
  • [21] INSULIN RESISTANCE IN ACROMEGALY - DEFECTS IN BOTH HEPATIC AND EXTRAHEPATIC INSULIN ACTION
    HANSEN, I
    TSALIKIAN, E
    BEAUFRERE, B
    GERICH, J
    HAYMOND, M
    RIZZA, R
    AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 250 (03): : E269 - E273
  • [22] Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats
    Song, XM
    Kawano, Y
    Krook, A
    Ryder, JW
    Efendic, S
    Roth, RA
    Wallberg-Henriksson, H
    Zierath, JR
    DIABETES, 1999, 48 (03) : 664 - 670
  • [23] Insulin Receptors and Their Signal Transduction Pathways in Choroid Plexus
    Mazucanti, Caio
    Kennedy, Vernon L.
    Cho, Andrew
    Liu, Qing-Rong
    O'Connell, Jennifer F.
    Camandola, Simonetta
    Egan, Josephine M.
    DIABETES, 2022, 71
  • [24] INSULIN AND IGF RECEPTORS IN CELLULAR SIGNAL-TRANSDUCTION
    GAMMELTOFT, S
    ANNALES DE BIOLOGIE CLINIQUE, 1993, 51 (3-5) : 247 - 248
  • [25] Insulin resistance in the polycystic ovary syndrome involves intrinsic defects in skeletal muscle glucose uptake and insulin action
    Ciaraldi, TP
    Chu, NV
    Aroda, V
    Bandukwala, R
    Chandran, M
    Coffler, MS
    Chang, RJ
    Mudaliar, SR
    Henry, RR
    DIABETES, 2002, 51 : A298 - A298
  • [26] Insulin and insulin-like growth factor I receptors: Similarities and differences in signal transduction
    Dupont, J
    LeRoith, D
    HORMONE RESEARCH, 2001, 55 : 22 - 26
  • [27] ACTION OF DIGOXIN AND INSULIN ON THE GLUCOSE TRANSPORT OF THE MYOCARDIUM
    KIEN, GA
    GOMOLL, AW
    SHERROD, TR
    FEDERATION PROCEEDINGS, 1960, 19 (01) : 116 - 116
  • [28] IMPORTANCE OF TRANSCAPILLARY INSULIN TRANSPORT TO DYNAMICS OF INSULIN ACTION AFTER INTRAVENOUS GLUCOSE
    ADER, M
    BERGMAN, RN
    AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (01): : E17 - E25
  • [29] Glucose transport: Pivotal step in insulin action
    Kahn, BB
    DIABETES, 1996, 45 (11) : 1644 - 1654
  • [30] SIGNAL-TRANSDUCTION PATHWAYS FROM INSULIN-RECEPTORS TO RAS - ANALYSIS BY MUTANT INSULIN-RECEPTORS
    YONEZAWA, K
    ANDO, A
    KABURAGI, Y
    YAMAMOTOHONDA, R
    KITAMURA, T
    HARA, K
    NAKAFUKU, M
    OKABAYASHI, Y
    KADOWAKI, T
    KAZIRO, Y
    KASUGA, M
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1994, 269 (06) : 4634 - 4640
12345