Non-vaccine Pneumococcal Serotypes Among Children with Invasive Pneumococcal Disease
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John, James
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Christian Med Coll & Hosp, Dept Clin Microbiol, Vellore 632004, Tamil Nadu, IndiaChristian Med Coll & Hosp, Dept Clin Microbiol, Vellore 632004, Tamil Nadu, India
John, James
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Varghese, Rosemol
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Christian Med Coll & Hosp, Dept Clin Microbiol, Vellore 632004, Tamil Nadu, IndiaChristian Med Coll & Hosp, Dept Clin Microbiol, Vellore 632004, Tamil Nadu, India
Varghese, Rosemol
[1
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Lionell, Jones
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Christian Med Coll & Hosp, Dept Clin Microbiol, Vellore 632004, Tamil Nadu, IndiaChristian Med Coll & Hosp, Dept Clin Microbiol, Vellore 632004, Tamil Nadu, India
Lionell, Jones
[1
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Neeravi, Ayyanraj
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Christian Med Coll & Hosp, Dept Clin Microbiol, Vellore 632004, Tamil Nadu, IndiaChristian Med Coll & Hosp, Dept Clin Microbiol, Vellore 632004, Tamil Nadu, India
Neeravi, Ayyanraj
[1
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Veeraraghavan, Balaji
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Christian Med Coll & Hosp, Dept Clin Microbiol, Vellore 632004, Tamil Nadu, IndiaChristian Med Coll & Hosp, Dept Clin Microbiol, Vellore 632004, Tamil Nadu, India
Veeraraghavan, Balaji
[1
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[1] Christian Med Coll & Hosp, Dept Clin Microbiol, Vellore 632004, Tamil Nadu, India
ObjectiveTo report the percentage of non-vaccine pneumococcal serotypes and their antibiotic susceptibility pattern in children with invasive peumococcal disease.MethodsInvasive pneumococcal isolates of children <5 years during January 2007 to December 2016 were serotyped by a co-agglutination reaction and sequential multiplex polymerase chain reaction.ResultsAmong the total 170 S. pneumoniae invasive isolates, 54 (31.8%) and 44 (25.9 %) were the serotypes, which are not included in current 10-valent or 13-valent vaccines, respectively. Very low resistance was observed against penicillin (4.5%) and all isolates were susceptible to cefotaxime.ConclusionsOne-fourth to one-third of the S. pneumoniae serotypes in under-five children with invasive pneumococcal disease are not covered by existing pneumococcal vaccines in India.
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Capital Med Univ, Natl Ctr Childrens Hlth, Key Lab Major Dis Children, Beijing Pediat Res Inst,Beijing Childrens Hosp,Mi, Beijing 100045, Peoples R ChinaCapital Med Univ, Natl Ctr Childrens Hlth, Key Lab Major Dis Children, Beijing Pediat Res Inst,Beijing Childrens Hosp,Mi, Beijing 100045, Peoples R China
Du, Qian-qian
Shi, Wei
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Capital Med Univ, Natl Ctr Childrens Hlth, Key Lab Major Dis Children, Beijing Pediat Res Inst,Beijing Childrens Hosp,Mi, Beijing 100045, Peoples R ChinaCapital Med Univ, Natl Ctr Childrens Hlth, Key Lab Major Dis Children, Beijing Pediat Res Inst,Beijing Childrens Hosp,Mi, Beijing 100045, Peoples R China
Shi, Wei
Yu, Dan
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Capital Med Univ, Natl Ctr Childrens Hlth, Key Lab Major Dis Children, Beijing Pediat Res Inst,Beijing Childrens Hosp,Mi, Beijing 100045, Peoples R ChinaCapital Med Univ, Natl Ctr Childrens Hlth, Key Lab Major Dis Children, Beijing Pediat Res Inst,Beijing Childrens Hosp,Mi, Beijing 100045, Peoples R China
Yu, Dan
Yao, Kai-hu
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Capital Med Univ, Natl Ctr Childrens Hlth, Key Lab Major Dis Children, Beijing Pediat Res Inst,Beijing Childrens Hosp,Mi, Beijing 100045, Peoples R ChinaCapital Med Univ, Natl Ctr Childrens Hlth, Key Lab Major Dis Children, Beijing Pediat Res Inst,Beijing Childrens Hosp,Mi, Beijing 100045, Peoples R China