Non-vaccine Pneumococcal Serotypes Among Children with Invasive Pneumococcal Disease

被引：1
|
作者：
John, James [1 ]
Varghese, Rosemol [1 ]
Lionell, Jones [1 ]
Neeravi, Ayyanraj [1 ]
Veeraraghavan, Balaji [1 ]
机构：
[1] Christian Med Coll & Hosp, Dept Clin Microbiol, Vellore 632004, Tamil Nadu, India
来源：
INDIAN PEDIATRICS | 2018年 / 55卷 / 10期
关键词：
Immunization schedule; Streptococcus pneumoniae; Vaccination; STREPTOCOCCUS-PNEUMONIAE; CONJUGATE VACCINE;
D O I：
10.1007/s13312-018-1398-x
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
ObjectiveTo report the percentage of non-vaccine pneumococcal serotypes and their antibiotic susceptibility pattern in children with invasive peumococcal disease.MethodsInvasive pneumococcal isolates of children <5 years during January 2007 to December 2016 were serotyped by a co-agglutination reaction and sequential multiplex polymerase chain reaction.ResultsAmong the total 170 S. pneumoniae invasive isolates, 54 (31.8%) and 44 (25.9 %) were the serotypes, which are not included in current 10-valent or 13-valent vaccines, respectively. Very low resistance was observed against penicillin (4.5%) and all isolates were susceptible to cefotaxime.ConclusionsOne-fourth to one-third of the S. pneumoniae serotypes in under-five children with invasive pneumococcal disease are not covered by existing pneumococcal vaccines in India.
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页码：874 / 876
页数：3
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