Bioactive metabolites of the marine actinobacterium Streptomyces sp KMM 7210

被引：13
|
作者：
Sobolevskaya, M. P. [1 ]
Denisenko, V. A. [1 ]
Moiseenko, A. S. [1 ]
Shevchenko, L. S. [1 ]
Menzorova, N. I. [1 ]
Sibirtsev, Yu. T. [1 ]
Kim, N. Yu. [1 ]
Kuznetsova, T. A. [1 ]
机构：
[1] Russian Acad Sci, Pacific Inst Bioorgan Chem, Far E Div, Vladivostok 690022, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2007年 / 56卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
marine actinobacteria Streptomyces sp; piperazine-2; 5-diones; N-acetyl-tyramine; biologically active substances;
D O I：
10.1007/s11172-007-0126-9
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
New 3-(4-hydroxybenzyl)piperazine-2,5-dione, together with the known N-[2-(4-hydroxy-phenyl)ethyl]acetamide (N-acetyltyramine), was isolated for the first time from the marine actinobacterium Streptomyces sp. The chemical structures of these compounds were determined by NMR spectroscopy and mass spectrometry. The cytotoxic activities of the compounds were estimated from their effects on sperm and eggs of the sea urchin Strongylocentrotus intermedius.
引用
收藏
页码：838 / 840
页数：3
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