Ectoine Biosynthesis in Mycobacterium smegmatis

被引：36

作者：

Ofer, Naomi ^{[1
]}

Wishkautzan, Marina ^{[1
,2
]}

Meijler, Michael M. ^{[2
,3
]}

Wang, Ying ^{[4
]}

Speer, Alexander ^{[4
]}

Niederweis, Michael ^{[4
]}

Gur, Eyal ^{[1
,2
]}

机构：

[1] Ben Gurion Univ Negev, Dept Life Sci, IL-84105 Beer Sheva, Israel

[2] Ben Gurion Univ Negev, Natl Inst Biotecnol Negev, IL-84105 Beer Sheva, Israel

[3] Ben Gurion Univ Negev, Dept Chem, Beer Sheva, Israel

[4] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2012年 / 78卷 / 20期

关键词：

COMPATIBLE SOLUTE ECTOINE; SALT-SENSITIVE MUTANTS; INHIBIT AGGREGATION; HALOMONAS-ELONGATA; HYDROXYECTOINE; OSMOADAPTATION; NEUROTOXICITY; STABILIZATION; BACTERIA; ARCHAEA;

D O I：

10.1128/AEM.01318-12

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mycobacterium smegmatis is a commonly used mycobacterial model system. Here, we show that M. smegmatis protects itself against elevated salinity by synthesizing ectoine and hydroxyectoine and characterize the phenotype of a nonproducing mutant. This is the first analysis of M. smegmatis halotolerance and of the molecular mechanism that supports it.

引用

页码：7483 / 7486

页数：4

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