Cytological features of NUT-carcinoma harbouring an NSD3-NUTM1 fusion

被引：1
|
作者：
Argyropoulos, Kimon, V [1 ]
Lin, Lawrence Hsu [1 ]
Moreira, Andre L. [2 ]
Krock, Bryan [3 ]
Simsir, Aylin [1 ]
Brandler, Tamar C. [1 ]
机构：
[1] NYU, Sch Med, Dept Pathol, Div Cytopathol, New York, NY 10012 USA
[2] NYU, Sch Med, Dept Pathol, Div Thorac Pathol, New York, NY USA
[3] Caris Life Sci, Phoenix, AZ USA
来源：
CYTOPATHOLOGY | 2022年 / 33卷 / 04期
关键词：
MIDLINE CARCINOMA; ONCOPROTEIN;
D O I：
10.1111/cyt.13120
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
NUT (Nuclear protein of the testis)-carcinomas are uncommon malignancies that are even less frequently encountered as cytological specimens. Here we present a case of a pulmonary NUT-carcinoma diagnosed on wash cytology with cell block preparation, characterised by the unusual NUT fusion variant, NSD3-NUTM1. Given the limited information on the cytological features of NUT-carcinomas, including partners beyond the classic BRD4 or BRD3 genes and especially NUTM1 fusion variants, it is important to provide more of these cases in the literature so that they can be readily distinguished from morphologically and immunohistochemically similar neoplasms.
引用
收藏
页码：540 / 543
页数：4
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