A functional perspective on phenotypic heterogeneity in microorganisms

被引：573
|
作者：
Ackermann, Martin [1 ,2 ]
机构：
[1] ETH, ETH Zentrum CHN H70 3, Swiss Fed Inst Technol Zurich, Inst Biogeochem & Pollutant Dynam, CH-8092 Zurich, Switzerland
[2] Swiss Fed Inst Aquat Sci & Technol Eawag, Dept Environm Microbiol, CH-8600 Dubendorf, Switzerland
来源：
NATURE REVIEWS MICROBIOLOGY | 2015年 / 13卷 / 08期
基金：
瑞士国家科学基金会;
关键词：
STOCHASTIC GENE-EXPRESSION; SINGLE CELLS; NOISE; DIVERSITY; EVOLUTION; MICROBES; INDIVIDUALITY; VARIABILITY; COOPERATION; SELECTION;
D O I：
10.1038/nrmicro3491
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Most microbial communities consist of a genetically diverse assembly of different organisms, and the level of genetic diversity plays an important part in community properties and functions. However, biological diversity also arises at a lower level of biological organization, between genetically identical cells that reside in the same microenvironment. In this Review, I outline the molecular mechanisms responsible for phenotypic heterogeneity and discuss how phenotypic heterogeneity allows genotypes to persist in fluctuating environments. I also describe how it promotes interactions between phenotypic subpopulations in clonal groups, providing microbial groups with new functionality.
引用
收藏
页码：497 / 508
页数：12
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