Characterizing the mechanism and the clinical relevance of the synthetic lethal interaction between STAT3 inhibition and HER2 overexpression in breast cancers

被引：1
|
作者：
Barrueco, Ruth Rodriguez [1 ]
Yu, Jiyang [1 ]
Alvarez, Mariano [1 ]
Castro, Veronica [1 ]
Marshall, Netonia [1 ]
Su, Ruoxi [1 ]
Castro, Laura [1 ]
Maurer, Matthew [1 ]
Califano, Andrea [1 ]
Silva, Jose M. [1 ]
机构：
[1] Columbia Univ, New York, NY USA
来源：
CANCER RESEARCH | 2014年 / 74卷 / 19期
关键词：
D O I：
10.1158/1538-7445.AM2014-2761
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2761
引用
收藏
页数：2
相关论文
共 46 条
  • [31] Pseudo-temporal dynamics of chemoresistant triple negative breast cancer cells reveal EGFR/HER2 inhibition as synthetic lethal during mid-neoadjuvant chemotherapy
    Song, Won -Min
    Chia, Pei-Ling
    Zhou, Xianxiao
    Walsh, Martin
    Silva, Jose
    Zhang, Bin
    ISCIENCE, 2023, 26 (02)
  • [32] FoxP3 expression in luminal A, luminal B, HER2 overexpressors and Triple Negative Breast Cancers (TNBC): A clinical & immunohistochemical correlation study
    Vidak, J.
    Ali, N.
    Trivedi, P.
    Ramakrishnan, R.
    VIRCHOWS ARCHIV, 2013, 463 (02) : 250 - 250
  • [33] Focal adhesion kinase (FAK) mediates fibroblast-induced HER2+breast cancer cell migration and invasion through a mechanism involving Stat3
    Lazaro, Glorianne
    Smith, Chris
    Hiscox, Stephen
    CANCER RESEARCH, 2014, 74 (19)
  • [34] STAT3 and GLI1/tGLI1 oncogenic transcription factors interact to promote the aggressiveness of triple-negative and HER2-enriched breast cancers
    Sirkisoon, Sherona R.
    Carpenter, Richard L.
    Tadas, Rimkus
    Ashley, Anderson
    Harrison, Alexandria
    Lange, Allison M.
    Jin, Guangxu
    Watabe, Kounosuke
    Lo, Hui-Wen
    CANCER RESEARCH, 2018, 78 (13)
  • [35] TrkA Interacts with and Phosphorylates STAT3 to Enhance Gene Transcription and Promote Breast Cancer Stem Cells in Triple-Negative and HER2-Enriched Breast Cancers (vol 13, 2340, 2021)
    Regua, Angelina T.
    Aguayo, Noah R.
    Jalboush, Sara Abu
    Doheny, Daniel L.
    Manore, Sara G.
    Zhu, Dongqin
    Wong, Grace L.
    Arrigo, Austin
    Wagner, Calvin J.
    Yu, Yang
    Thomas, Alexandra
    Chan, Michael D.
    Ruiz, Jimmy
    Jin, Guangxu
    Strowd, Roy
    Sun, Peiqing
    Lin, Jiayuh
    Lo, Hui-Wen
    CANCERS, 2024, 16 (19)
  • [36] HER2 immunohistochemistry (IHC) expression in HER2-positive (HER2pos) metastatic breast cancer (mBC): clinical and prognostic differences between IHC 2+and IHC 3+populations
    Dri, Arianna
    Blondeaux, Eva
    Bighin, Claudia
    Gasparro, Simona
    Russo, Stefania
    Foffano, Lorenzo
    Pugliese, Palma
    Fontana, Andrea
    Cortesi, Enrico
    Ferzi, Antonella
    Riccardi, Ferdinando
    Sini, Valentina
    Boni, Luca
    Fabi, Alessandra
    Montemurro, Filippo
    De Laurentiis, Michelino
    Arpino, Grazia
    Del Mastro, Lucia
    Gerratana, Lorenzo
    Puglisi, Fabio
    CANCER RESEARCH, 2024, 84 (09)
  • [37] Synthetic lethal interaction between SETD2 loss and inhibition of PI3Kβ in clear cell renal cell carcinoma (ccRCC)
    Terzo, Esteban
    Chiang, Yun C.
    Chytil, Anna
    Jansen, Valerie M.
    Rathmell, Kimryn
    CANCER RESEARCH, 2018, 78 (13)
  • [38] Clinical Dose Preparation of [177Lu]Lu-DOTA-Pertuzumab Using Medium Specific Activity [177Lu]LuCl3 for Radioimmunotherapy of Breast and Epithelial Ovarian Cancers, with HER2 Receptor Overexpression
    Menon, Sreeja Raj
    Mitra, Arpit
    Chakraborty, Avik
    Tawate, Megha
    Sahu, Sudeep
    Rakshit, Sutapa
    Gaikwad, Sujay
    Dhotre, Geetanjali
    Damle, Archana
    Banerjee, Sharmila
    CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 2022, 37 (05) : 384 - 402
  • [39] Tamoxifen-induced ER-α-SRC-3 interaction in HER2 positive human breast cancer;: a possible mechanism for ER isoform specific recurrence
    Mc Ilroy, Marie
    Fleming, Fergal J.
    Buggy, Yvonne
    Hill, Arnold D. K.
    Young, Leonie S.
    ENDOCRINE-RELATED CANCER, 2006, 13 (04) : 1135 - 1145
  • [40] JAK2/STAT3 and TrkA pathways are frequently co-activated in triple-negative and HER2-enriched breast cancers and the co-activation correlates with an increased potential of metastasis.
    Regua, Angelina T.
    Aguayo, Noah R.
    Abu Jalboush, Sara
    Doheny, Daniel L.
    Manore, Sara G.
    Zhu, Dongqin
    Wong, Grace L.
    Arrigo, Austin
    Wagner, Calvin J.
    Yu, Yang
    Baylon, Karen
    Thomas, Alexandra
    Chan, Michael D.
    Ruiz, Jimmy
    Jin, Guangxu
    Strowd, Roy E.
    Sun, Peiqing
    Metheny-Barlow, Linda J.
    Lin, Jiayuh
    Lo, Hui-Wen
    CANCER RESEARCH, 2021, 81 (13)
12345