Age-dependent regulation of seizure activity by nitric oxide in the developing rat

被引：0
|
作者：
de Vasconcelos, AP [1 ]
Marescaux, C [1 ]
Nehlig, A [1 ]
机构：
[1] Fac Med, INSERM 398, F-67085 Strasbourg, France
来源：
DEVELOPMENTAL BRAIN RESEARCH | 1998年 / 107卷 / 02期
关键词：
nitric oxide; seizure; status epilepticus; development; L-arginine; N-G-nitro-L-arginine;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The role of nitric oxide (NO) on the age-dependent selective vulnerability to the consequences of epileptic seizures was studied in 10-day old (P10) and 21-day old (P21) rats. At P10, the NO synthase (NOS) inhibitor, NG-nitro-L-arginine (LNA), increased severity of seizures while L-arginine (L-Arg), the NOS substrate, had no effect. At P21, L-Arg improved the outcome of seizures while LNA had no effect. These results demonstrated the age-dependent role of NO in epilepsy. (C) 1998 Elsevier Science B.V.
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页码：315 / 319
页数：5
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