FGF21 and the Second Coming of PPARγ

被引：24
|
作者：
Qiang, Li [1 ,2 ]
Accili, Domenico [1 ,2 ]
机构：
[1] Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA
[2] Columbia Univ Coll Phys & Surg, Berrie Diabet Ctr, New York, NY 10032 USA
来源：
CELL | 2012年 / 148卷 / 03期
关键词：
ACTIVATED-RECEPTOR-GAMMA; FIBROBLAST-GROWTH-FACTOR-21; STATES; GENES; ALPHA;
D O I：
10.1016/j.cell.2012.01.020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Peptide hormone fibroblast growth factor-21 (FGF21) has insulin-mimetic properties. Dutchak et al. now suggest that FGF21 also acts in an autocrine fashion in adipocytes and is required to mediate effects of the PPAR gamma agonist class of antidiabetic drugs. Does this new property improve FGF21's fledgling clinical prospects or endorse a clinical resuscitation of PPAR gamma agonists?
引用
收藏
页码：397 / 398
页数：2
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