Antibody levels in children after 10 years of vaccination against hepatitis B: a Brazilian community-based study

被引：3

作者：

Fagundes, Glauco Danielle ^{[1
]}

Tabalipa, Fabio de Oliveira ^{[2
]}

da Silva, Jane ^{[2
,3
]}

机构：

[1] Univ Extremo Sul Catarinense, Dept Med, Criciuma, SC, Brazil

[2] Univ Sul Santa Catarina, Dept Med, Palhoca, SC, Brazil

[3] Univ Sul Santa Catarina, Programa Posgrad Ciencias Saude, Palhoca, SC, Brazil

来源：

REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2012年 / 45卷 / 02期

关键词：

Hepatitis B virus; Vaccination; Anti-HBs; Anti-HBc; HBsAg; PROTECTION; BIRTH;

D O I：

10.1590/S0037-86822012000200024

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Introduction: It is known that the hepatitis B (HB) vaccine is effective, but it is alarming that sudden drops of antibody levels may coincide with the onset of adolescence. Methods: Antibody levels against HB vaccine surface antigen (anti-HBs) and HB vaccine core antigen (anti-HBc) were measured on the blood samples of children with a mean age of 11.4 years. Results: About 54.8% had protective levels of anti-HBs. Of those who were anti-HBc-positive (4.4%), an average of 218.4 anti-HBs mIU/mL was found. Conclusions: Immunological protection was found in the majority of children. However, more studies are needed to elucidate the heritability of nonresponders and establish strategies against such events.

引用

页码：260 / 262

页数：3

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