The inhibition of the mitochondrial F1F0-ATPase activity when activated by Ca2+ opens new regulatory roles for NAD+

被引：4

作者：

Nesci, Salvatore ^{[1
]}

Trombetti, Fabiana ^{[1
]}

Ventrella, Vittoria ^{[1
]}

Pirini, Maurizio ^{[1
]}

Pagliarani, Alessandra ^{[1
]}

机构：

[1] Univ Bologna, Dept Vet Med Sci DIMEVET, Via Tolara Sopra 50, I-40064 Ozzano Dellemilia, BO, Italy

来源：

BIOLOGICAL CHEMISTRY | 2018年 / 399卷 / 02期

关键词：

Ca2+ cofactor; F1F0-ATPase; mitochondria; NAD(+); PERMEABILITY TRANSITION PORE; MUSSEL DIGESTIVE GLAND; MG-ATPASE ACTIVITY; SYNTHASE; SIRTUINS; F1FO-ATPASE; MECHANISM; DISEASE; NICOTINAMIDE; REPLACEMENT;

D O I：

10.1515/hsz-2017-0209

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mitochondrial F1F0-ATPase is uncompetitively inhibited by NAD(+) only when the natural cofactor Mg2+ is replaced by Ca2+, a mode putatively involved in cell death. The Ca2+-dependent F1F0-ATPase is also inhibited when NAD(+) concentration in mitochondria is raised by acetoacetate. The enzyme inhibition by NAD(+) cannot be ascribed to any de-ac(et)ylation or ADP-ribosylation by sirtuines, as it is not reversed by nicotinamide. Moreover, the addition of acetyl-CoA or palmitate, which would favor the enzyme ac(et)ylation, does not affect the F1F0-ATPase activity. Consistently, NAD(+) may play a new role, not associated with redox and non-redox enzymatic reactions, in the Ca2+-dependent regulation of the F1F0-ATPase activity.

引用

页码：197 / 202

页数：6

共 32 条

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