(1R*,5S*)-8-(2-Fluoro-4-nitrophenyl)-8-azabicyclo[3.2.1]octan-3-one

被引：0
|
作者：
Yang, Tao [1 ]
Yang, Jianzhong [1 ]
Li, Zicheng [2 ]
Luo, Youfu [1 ]
机构：
[1] Sichuan Univ, W China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
[2] Sichuan Univ, Sch Chem Engn, Dept Pharmaceut & Bioengn, Chengdu 610065, Peoples R China
来源：
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2011年 / 67卷
关键词：
data-to-parameter ratio = 11.5; disorder in main residue; mean σ(C-C) = 0.003 Å; R factor = 0.044; single-crystal X-ray study; T = 293 K; wR factor = 0.113;
D O I：
10.1107/S1600536811047350
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
In the title compound, C13H13FN2O3, the fused piperidine ring is in a chair conformation. The fused pyrrolidine ring shows an envelope conformation with the N atom displaced by 0.661 (3) angstrom out of the plane formed by the four C atoms of the pyrrolidine ring. The dihedral angle between this plane and the plane formed by the four attached C atoms of the piperidine ring (not including the carbonyl C atom) is 67.63 (10)degrees. The F atom is disordered and was refined using a split model with an occupancy ratio of 0.910 (3): 0.080 (3).
引用
收藏
页码：O3297 / U1809
页数：8
相关论文
共 50 条
  • [21] SYNTHESIS OF N-ACETYL DERIVATIVES OF (1R,5R)-6-AZA-2-OXABICYCLO[3.3.0]-OCTAN-3-ONE AND (1S,5R,8R)-8-O-BENZYL-6-AZA-2-OXABICYCLO[3.3.0]OCTAN-3-ONE FROM D-GLUCOSE
    GURJAR, MK
    PATIL, VJ
    PAWAR, SM
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1987, 26 (12): : 1115 - 1120
  • [22] ELECTROCHEMICAL REDUCTION OF 8-(2-CYANOETHYL)-8-AZABICYCLO[3,2,1]OCT-3-EN-2-ONE
    ELASKALANI, AH
    ELABBADY, SA
    ALAHMADY, AA
    ELMAGD, AMA
    MOUSTAFA, AH
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1992, 69 (06) : 306 - 309
  • [23] Synthesis of 2-substituted 8-azabicyclo[3.2.1]octan-3-ones in aqueous NaOH solution of low concentration
    Department of Chemistry, Dong-A University, Busan 604-714, Korea, Republic of
    不详
    Bull. Korean Chem. Soc., 2006, 9 (1493-1496):
  • [24] Synthesis and properties of N-substituted (1R,5S)-4-aminomethylidene-1,8,8-trimethyl-2-oxabicyclo[3.2.1]octan-2-ones
    Groselj, U
    Bevk, D
    Jakse, R
    Meden, A
    Pirc, S
    Recnik, S
    Stanovnik, B
    Svete, J
    TETRAHEDRON-ASYMMETRY, 2004, 15 (15) : 2367 - 2383
  • [25] Synthesis of 2-substituted 8-azabicyclo[3.2.1]octan-3-ones in aqueous NaOH solution of low concentration
    Jung, Dai-il
    Song, Ju-hyun
    Lee, Do-hun
    Kim, Yong-hwan
    Lee, Yong-gyun
    Hahn, Jung-tai
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2006, 27 (09) : 1493 - 1496
  • [26] SYNTHESIS AND POLYMERIZATION OF AN OPTICALLY-ACTIVE BICYCLIC OXALACTAM - A NOVEL HYDROPHILIC POLYAMIDE MEMBRANE PREPARED FROM (+)-(1R,5S)-8-OXA-6-AZABICYCLO[3.2.1]OCTAN-7-ONE
    HASHIMOTO, K
    SUMITOMO, H
    MACROMOLECULES, 1980, 13 (04) : 786 - 791
  • [27] STRUCTURE OF (1R,5S,8R)-8-METHOXY-3,3-DIMETHYL-2,4,7-TRIOXABICYCLO-[3.3.0]OCTAN-6-ONE
    PAPAIOANNOU, D
    FRANCIS, GW
    MAARTMANNMOE, K
    ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1990, 46 : 156 - 158
  • [28] (1R,2R,4S,5S)-1,2,4,8,8-pentamethyl-3-thia-bicyclo-[3.2.1]octane 3,3-dioxide
    Li, Xin-Liang
    Gui, Yuan
    Huang, Kun
    Li, Yi-Zhi
    Huang, Zhi-Zhen
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O2411 - O2412
  • [29] Synthesis of potential metabolites of the brain imaging agents methyl (1R,2S,3S,5S)-3-(4-iodophenyl)-8-alkyl-8-azabicyclo[3.2.1]octane-2-carboxylate
    Andersen, A
    Wang, SY
    Thompson, RD
    Neumeyer, JL
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1997, 34 (05) : 1633 - 1636
  • [30] Synthesis of (1R,4E,5S)-4-{[(E)-(azinyl)diazenyl]methylidene}-1,8,8-trimethyl-2-oxabicyclo[3.2.1]octan-3-ones and (1R,4R,5R)-4-[1,2,4]triazolo[4,3-x]azin-3-yl)-1,8,8-trimethyl-2-oxabicyclo[3.2.1]octan-3-ones
    Groselj, U
    Bevk, D
    Jakse, R
    Meden, A
    Stanovnik, B
    Svete, J
    TETRAHEDRON-ASYMMETRY, 2005, 16 (17) : 2927 - 2945
12345