Crystal structure of Rv3899c184-410, a hypothetical protein from Mycobacterium tuberculosis

被引：3
|
作者：
Liu, Yingying [1 ]
Gao, Yunrong [2 ,3 ]
Li, Defeng [2 ,3 ]
Fleming, Joy [2 ,3 ]
Li, Honglin [1 ]
Bi, Lijun [1 ,2 ,3 ]
机构：
[1] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China
[2] Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, 15 Datun Rd, Beijing 100101, Peoples R China
[3] Chinese Acad Sci, Inst Biophys, Lab Noncoding RNA, 15 Datun Rd, Beijing 100101, Peoples R China
来源：
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS | 2016年 / 72卷
基金：
中国国家自然科学基金;
关键词：
Mycobacterium tuberculosis; Rv3899c(184-410); crystal structure; CALMETTE; FEATURES;
D O I：
10.1107/S2053230X16010943
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Rv3899c is a hypothetical protein from Mycobacterium tuberculosis which is conserved across mycobacteria. It is predicted to be secreted and has been found in culture filtrates. It has been proposed as a potential vaccine candidate; however, its biological function is unknown. Here, the global structure of Rv3899c(184-410), a fragment of Rv3899c, is reported. The structure resembles the shell of a sea snail, and its N- and C-termini form two relatively independent compact domains: an alpha/beta/alpha sandwich folding domain and an alpha-helix bundle domain. There are no reported protein structures for any Rv3899c homologues; this structure provides the first structural glimpse of a new protein family consisting of Rv3899c and its homologues.
引用
收藏
页码：642 / 645
页数：4
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