Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in Clinical Practice

被引：30
|
作者：
Tafazoli, Alireza [1 ,2 ]
Guchelaar, Henk-Jan [3 ,4 ]
Miltyk, Wojciech [1 ]
Kretowski, Adam J. [2 ,5 ]
Swen, Jesse J. [3 ,4 ]
机构：
[1] Med Univ Bialystok, Fac Pharm, Dept Anal & Bioanal Med, Div Lab Med, Bialystok, Poland
[2] Med Univ Bialystok, Clin Res Ctr, Bialystok, Poland
[3] Leiden Univ, Dept Clin Pharm & Toxicol, Med Ctr, Leiden, Netherlands
[4] Leiden Network Personalized Therapeut, Leiden, Netherlands
[5] Med Univ Bialystok, Dept Endocrinol Diabetol & Internal Med, Bialystok, Poland
来源：
FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷
基金：
欧盟地平线“2020”;
关键词：
pharmacogenomics; clinical implementation; next generation sequencing; clinical practice; PGx testing; IMPLEMENTATION CONSORTIUM; INCIDENTAL FINDINGS; CYP2D6; DRUG; GENOTYPE; CHALLENGES; EXOME; RECOMMENDATIONS; INFORMATION; MUTATIONS;
D O I：
10.3389/fphar.2021.693453
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Pharmacogenomics (PGx) studies the use of genetic data to optimize drug therapy. Numerous clinical centers have commenced implementing pharmacogenetic tests in clinical routines. Next-generation sequencing (NGS) technologies are emerging as a more comprehensive and time- and cost-effective approach in PGx. This review presents the main considerations for applying NGS in guiding drug treatment in clinical practice. It discusses both the advantages and the challenges of implementing NGS-based tests in PGx. Moreover, the limitations of each NGS platform are revealed, and the solutions for setting up and management of these technologies in clinical practice are addressed.
引用
收藏
页数：15
相关论文
共 50 条
  • [11] Next-Generation Sequencing (NGS): Platforms and Applications
    Mandlik, Jyoti S.
    Patil, Amol S.
    Singh, Sarita
    JOURNAL OF PHARMACY AND BIOALLIED SCIENCES, 2024, 16 : S41 - S45
  • [12] Clinical application of embryo aneuploidy testing by next-generation sequencing
    Rubio, Carmen
    Rodrigo, Lorena
    Garcia-Pascual, Carmen
    Peinado, Vanessa
    Campos-Galindo, Inmaculada
    Garcia-Herrero, Sandra
    Simon, Carlos
    BIOLOGY OF REPRODUCTION, 2019, 101 (06) : 1083 - 1090
  • [13] Integration of Next-Generation Sequencing Into Clinical Practice: Are We There Yet?
    Kohlmann, Alexander
    Grossmann, Vera
    Haferlach, Torsten
    SEMINARS IN ONCOLOGY, 2012, 39 (01) : 26 - 36
  • [14] Genetics of Pediatric Epilepsy: Next-Generation Sequencing in Clinical Practice
    Blazekovic, Antonela
    Gotovac Jercic, Kristina
    Meglaj, Sarah
    Duranovic, Vlasta
    Prpic, Igor
    Lozic, Bernarda
    Malenica, Masa
    Markovic, Silvana
    Lujic, Lucija
    Gadze, Zeljka Petelin
    Juraski, Romana Gjergja
    Barisic, Nina
    Baric, Ivo
    Borovecki, Fran
    GENES, 2022, 13 (08)
  • [15] Assuring the quality of next-generation sequencing in clinical laboratory practice
    Amy S Gargis
    Lisa Kalman
    Meredith W Berry
    David P Bick
    David P Dimmock
    Tina Hambuch
    Fei Lu
    Elaine Lyon
    Karl V Voelkerding
    Barbara A Zehnbauer
    Richa Agarwala
    Sarah F Bennett
    Bin Chen
    Ephrem L H Chin
    John G Compton
    Soma Das
    Daniel H Farkas
    Matthew J Ferber
    Birgit H Funke
    Manohar R Furtado
    Lilia M Ganova-Raeva
    Ute Geigenmüller
    Sandra J Gunselman
    Madhuri R Hegde
    Philip L F Johnson
    Andrew Kasarskis
    Shashikant Kulkarni
    Thomas Lenk
    C S Jonathan Liu
    Megan Manion
    Teri A Manolio
    Elaine R Mardis
    Jason D Merker
    Mangalathu S Rajeevan
    Martin G Reese
    Heidi L Rehm
    Birgitte B Simen
    Joanne M Yeakley
    Justin M Zook
    Ira M Lubin
    Nature Biotechnology, 2012, 30 : 1033 - 1036
  • [16] Assuring the quality of next-generation sequencing in clinical laboratory practice
    Gargis, Amy S.
    Kalman, Lisa
    Berry, Meredith W.
    Bick, David P.
    Dimmock, David P.
    Hambuch, Tina
    Lu, Fei
    Lyon, Elaine
    Voelkerding, Karl V.
    Zehnbauer, Barbara A.
    Agarwala, Richa
    Bennett, Sarah F.
    Chen, Bin
    Chin, Ephrem L. H.
    Compton, John G.
    Das, Soma
    Farkas, Daniel H.
    Ferber, Matthew J.
    Funke, Birgit H.
    Furtado, Manohar R.
    Ganova-Raeva, Lilia M.
    Geigenmueller, Ute
    Gunselman, Sandra J.
    Hegde, Madhuri R.
    Johnson, Philip L. F.
    Kasarskis, Andrew
    Kulkarni, Shashikant
    Lenk, Thomas
    Liu, C. S. Jonathan
    Manion, Megan
    Manolio, Teri A.
    Mardis, Elaine R.
    Merker, Jason D.
    Rajeevan, Mangalathu S.
    Reese, Martin G.
    Rehm, Heidi L.
    Simen, Birgitte B.
    Yeakley, Joanne M.
    Zook, Justin M.
    Lubin, Ira M.
    NATURE BIOTECHNOLOGY, 2012, 30 (11) : 1033 - 1036
  • [17] Next-Generation sequencing transforming clinical practice and precision medicine
    Yadav, Deepali
    Patil-Takbhate, Bhagyashri
    Khandagale, Anil
    Bhawalkar, Jitendra
    Tripathy, Srikanth
    Khopkar-Kale, Priyanka
    CLINICA CHIMICA ACTA, 2023, 551
  • [18] A Flexible Clinical Laboratory Workflow for Single- or Multi-Gene Pharmacogenomic Testing Using Next-Generation Sequencing
    Deharvengt, S.
    Green, D.
    Green, J.
    Hackett, L.
    Ozmore, J.
    Brooks, G.
    Lewis, L.
    Tsongalis, G.
    Shah, P.
    Khan, W.
    JOURNAL OF MOLECULAR DIAGNOSTICS, 2024, 26 (11): : S143 - S144
  • [19] Base-calling for next-generation sequencing platforms
    Ledergerber, Christian
    Dessimoz, Christophe
    BRIEFINGS IN BIOINFORMATICS, 2011, 12 (05) : 489 - 497
  • [20] Tumour mutational burden ring trial: Evaluation of targeted next-generation sequencing platforms for implementation in clinical practice
    Lambin, S.
    Lambrechts, D.
    De Rop, C.
    D'Haene, N.
    Froyen, G.
    Heukamp, L.
    Huijsmans, C.
    Maes, B.
    Melendez, B.
    Van Campenhout, C.
    Vanden Bempt, I.
    van den Brule, A.
    Vander Borght, S.
    Vannuffel, P.
    Pauwels, P.
    ANNALS OF ONCOLOGY, 2019, 30
12345