Chlorine- and sulphur-substituted pyrrolo[ 3,4-b]quinolines and related derivatives arising from the aminolysis of 3,3,9-trichlorothieno[3,4-b]quinolin-1(3H)-one

被引：0
|
作者：
van Es, T [1 ]
Staskun, B
机构：
[1] Rutgers State Univ, Cook Coll, Dept Biochem & Microbiol, New Brunswick, NJ 08903 USA
[2] Univ Witwatersrand, Sch Chem, ZA-2050 Wits, South Africa
来源：
SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE | 2003年 / 56卷
关键词：
3,3,9-trichlorothieno[3,4-b]quinolin-1(3H)-one; aminolysis; 2-alkyl-9-chloro-3-thioxo-pyrrolo[3,4-b]quinolines; 2-alkyl-3-alkylimino-9-thioxo-pyrrolo[3,4-b]quinolines; 2-alkyl-9-alkylamino-3-alkylimino-pyrrolo[3,4-b]quinolines;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The outcome from aminolysis of 3,3,9-trichlorothieno[3,4-b] quinolinone with an alkylamine is dependent on the reaction conditions and extraneous reagents employed. A variety of hitherto unreported products can be obtained and include 4- chloro-2-alkylthiocarbamoyl-quinoline-3-carboxylic acid alkylamides, 9-chloro-2-alkyl-3-alkylimino-pyrrolo[3,4-b] quinolines, 9-chloro-2-alkyl-3-thioxo-pyrrolo[ 3,4- b]-quinolines, 2-alkyl-3-alkylimino-9-thioxo-pyrrolo[ 3,4- b] quinolines, and 2-alkyl-9-alkylamino-3-alkylimino-pyrrolo[3,4- b] quinolines. The spectral (H-1 NMR, HRMS) and chemical properties and the structures of the products are described and discussed, and possible mechanistic pathways leading to their formation are presented.
引用
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页码：40 / 46
页数：7
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