Synthesis of a new cerebroside isolated from Typhonium giganteum Engl

被引：0
|
作者：
Chen, XS
Wu, YL
Chen, DH
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China
[2] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100094, Peoples R China
[3] Peking Union Med Coll, Beijing 100094, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2003年 / 21卷 / 07期
关键词：
Typhonium giganteum Engl; natural product; cerebroside; chiron approach; synthesis;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The stereoselective synthesis of typhoniside, a new cerebroside isolated from Typhonium giganteum Engl. was accomplished. Cerebrosides are a kind of glycolipids highly enriched on the surface of myelin-producing cells and are composed by C18-4, 8-sphingadienine, alpha-hydroxy acid and a saccharide head. It was the first time that cerebrosides were isolated from this traditional Chinese medicine (TCM) by us. In this paper, C18-4, 8-sphingadienine was synthesized from D-xylose via a S(N)2 type reaction. a-Hydroxy acid was prepared from (R)4-hydroxytetrahydrofuran-2-one, which in turn could be obtained from L-ascorbic add.
引用
收藏
页码：937 / 943
页数：7
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