Hyperhomocysteinemia in dementia

被引：113
|
作者：
Leblhuber, F
Walli, J
Artner-Dworzak, E
Vrecko, K
Widner, B
Reibnegger, G
Fuchs, D
机构：
[1] Landesnervenklin Wagner Jauregg, Dept Gerontol, A-4020 Linz, Austria
[2] Univ Innsbruck, Inst Med Chem & Biochem, A-6020 Innsbruck, Austria
[3] Graz Univ, Inst Med Chem, A-8010 Graz, Austria
来源：
JOURNAL OF NEURAL TRANSMISSION | 2000年 / 107卷 / 12期
关键词：
homocysteine; dementia; Alzheimer's disease; vascular dementia; folic acid;
D O I：
10.1007/s007020070010
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Hyperhomocysteinemia is a strong risk factor for atherosclerotic vascular disease, and elevated serum homocysteine is correlated with vitamin B deficiency. In this pilot study, significantly elevated homocysteine levels were found in patients with Alzheimer's disease as well as in patients with vascular dementia, probably indicating similar pathophysiological pathways. We found significant correlations between low folic acid concentrations as well as high homocysteine concentrations and cognitive decline. Supplementation with folic acid may be an inexpensive way to reduce elevated homocysteine levels in demented patients.
引用
收藏
页码：1469 / 1474
页数：6
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