PARP inhibition causes replication stress in preclinical models of high risk neuroblastoma and synergises with inhibition of ATR

被引:0
|
作者
Southgate, Harriet [1 ]
Curtin, Nicola J. [1 ]
Tweddle, Deborah A. [1 ]
机构
[1] Newcastle Univ, Newcastle Upon Tyne, Tyne & Wear, England
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
57
引用
收藏
页码:20 / 20
页数:1
相关论文
共 50 条
  • [21] Evaluation of the effects of combined chemical inhibition of PARP and BET proteins in preclinical models of urothelial bladder cancer
    Maffuid, Kaitlyn A.
    Torrice, Chad D.
    Hardy, Brian
    Murphy, William A.
    James, Lindsey, I
    Kim, William Y.
    Frye, Stephen, V
    Pearce, Kenneth J.
    Crona, Daniel J.
    CANCER RESEARCH, 2020, 80 (16)
  • [22] Inhibition of Histone Deacetylase 3 Causes Replication Stress in Cutaneous T Cell Lymphoma
    Wells, Christina E.
    Bhaskara, Srividya
    Stengel, Kristy R.
    Zhao, Yue
    Sirbu, Bianca
    Chagot, Benjamin
    Cortez, David
    Khabele, Dineo
    Chazin, Walter J.
    Cooper, Andrew
    Jacques, Vincent
    Rusche, James
    Eischen, Christine M.
    McGirt, Laura Y.
    Hiebert, Scott W.
    PLOS ONE, 2013, 8 (07):
  • [23] MTA2 sensitizes gastric cancer cells to PARP inhibition by induction of DNA replication stress
    Shi, Jinwen
    Zhang, Xiaofeng
    Li, Jin'e
    Huang, Wenwen
    Wang, Yini
    Wang, Yi
    Qin, Jun
    TRANSLATIONAL ONCOLOGY, 2021, 14 (10):
  • [24] The oncoprotein DEK affects the outcome of PARP1/2 inhibition during mild replication stress
    Ganz, Magdalena
    Vogel, Christopher
    Czada, Christina
    Joerke, Vera
    Gwosch, Eva Christina
    Kleiner, Rebecca
    Pierzynska-Mach, Agnieszka
    Zanacchi, Francesca Cella
    Diaspro, Alberto
    Kappes, Ferdinand
    Buerkle, Alexander
    Ferrando-May, Elisa
    PLOS ONE, 2019, 14 (08):
  • [25] SF3B1-mutant cells succumb to replication stress under PARP inhibition
    Bland, Philip
    Natrajan, Rachael
    NATURE GENETICS, 2023, 55 (08) : 1265 - 1266
  • [26] Inhibition of protein synthesis with polyamine depletion in high-risk neuroblastoma
    Flynn, Andrea T.
    Liu, Kangning
    Vu, Annette
    Hogarty, Michael D.
    CANCER RESEARCH, 2018, 78 (13)
  • [27] SF3B1-mutant cells succumb to replication stress under PARP inhibition
    Nature Genetics, 2023, 55 : 1265 - 1266
  • [28] Differential therapeutic effects of PARP and ATR inhibition combined with radiotherapy in the treatment of subcutaneous versus orthotopic lung tumour models
    Vanessa Tran Chau
    Winchygn Liu
    Marine Gerbé de Thoré
    Lydia Meziani
    Michele Mondini
    Mark J. O’Connor
    Eric Deutsch
    Céline Clémenson
    British Journal of Cancer, 2020, 123 : 762 - 771
  • [29] Differential therapeutic effects of PARP and ATR inhibition combined with radiotherapy in the treatment of subcutaneous versus orthotopic lung tumour models
    Tran Chau, Vanessa
    Liu, Winchygn
    Gerbe de Thore, Marine
    Meziani, Lydia
    Mondini, Michele
    O'Connor, Mark J.
    Deutsch, Eric
    Clemenson, Celine
    BRITISH JOURNAL OF CANCER, 2020, 123 (05) : 762 - 771
  • [30] Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
    Syljuåsen, RG
    Sorensen, CS
    Hansen, LT
    Fugger, K
    Lundin, C
    Johansson, F
    Helleday, T
    Sehested, M
    Lukas, J
    Bartek, J
    MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (09) : 3553 - 3562