Thieno[2,3-d] pyrimidine as a promising scaffold in medicinal chemistry: Recent advances

被引：94

作者：

Ali, Eslam M. H. ^{[1
,2
]}

Abdel-Maksoud, Mohammed S. ^{[3
]}

Oh, Chang-Hyun ^{[1
,2
]}

机构：

[1] KIST, Ctr Biomat, Seoul 02792, South Korea

[2] UST, Dept Biomol Sci, Daejeon 34113, South Korea

[3] NRC, Pharmaceut & Drug Ind Res Div, Med & Pharmaceut Chem Dept, Giza 12622, Egypt

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2019年 / 27卷 / 07期

关键词：

Thienopyrimidine; Anti-inflammatory; Anticancer; Antimicrobial; Antiviral; CNS protective agents; RECEPTOR TYROSINE KINASE; INITIATION-FACTOR; 4E; BIOLOGICAL EVALUATION; DERIVATIVES BEARING; ANTICANCER ACTIVITY; 3-D PYRIMIDINE; THIENO; SUBSTITUTED THIENOPYRIMIDINES; STRUCTURAL MODIFICATIONS; ANTIBACTERIAL AGENTS;

D O I：

10.1016/j.bmc.2019.02.044

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thienopyrimidine scaffold is a fused heterocyclic ring system that structurally can be considered as adenine, the purine base that is found in both DNA and RNA-bioisosteres. Thienopyrimidines exist in three distinct isomeric forms. The current review discusses thieno[2,3-d] pyrimidine as a one of the opulent heterocycles in drug discovery. Its broad range of medical applications such as anticancer, anti-inflammatory, anti-microbial, and CNS protective agents has inspired us to study its structure-activity relationship (SAR), along with its relevant synthetic strategies. The present review briefly summarizes synthetic approaches for the preparation of thieno[2,3-d] pyrimidine derivatives. In addition, the promising biological activities of this scaffold are also illustrated with explanatory diagrams for their SAR studies.

引用

页码：1159 / 1194

页数：36

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