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- [24] Despite the lack of association between different genotypes and the presence of prostate cancer, endothelial nitric oxide Synthase a/b (eNOS4a/b) polymorphism may be associated with advanced clinical stage and bone metastasis (vol 29, pg 183, 2011) UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2011, 29 (04) : 467 - 467