A Novel Bionic Extracellular Matrix Polymer Scaffold Enhanced by Calcium Silicate for Bone Tissue Engineering

被引：10
|
作者：
Wang, Mei [1 ,2 ,3 ,4 ]
Li, Bowen [1 ,2 ,3 ,4 ]
Liu, Yuhua [1 ,2 ,3 ,4 ]
Tang, Lin [1 ,2 ,3 ,4 ]
Zhang, Yi [2 ,3 ,4 ,5 ]
Xie, Qiufei [1 ,2 ,3 ,4 ]
机构：
[1] Peking Univ, Dept Prosthodont, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
[2] Natl Ctr Stomatol, Beijing 100081, Peoples R China
[3] Natl Clin Res Ctr Oral Dis, Beijing 100081, Peoples R China
[4] Natl Engn Lab Digital & Mat Technol Stomatol, Beijing 100081, Peoples R China
[5] Peking Univ, Sch & Hosp Stomatol, Dept Gen Dent 2, Beijing, Peoples R China
来源：
ACS OMEGA | 2021年 / 6卷 / 51期
关键词：
SMALL-INTESTINAL SUBMUCOSA; POROUS SCAFFOLDS; REGENERATION; DEFECT; CELLS;
D O I：
10.1021/acsomega.1c05623
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel porous calcium silicate (CS)-enhanced small intestinal submucosa (SIS) scaffold was prepared by freeze-drying to mimic the natural extracellular matrix environment for bone tissue engineering. The micro-morphology, physicochemical properties, biological characteristics, and effects on osteogenic differentiation in vitro were explored; the effects on promoting bone formation in vivo were evaluated. The composite scaffold had an ideal three-dimensional porous structure. The amount of calcium silicate played a significant role in improving mechanical properties and promoting osteogenic differentiation. The SIS/2CS scaffold promoted proliferation and osteogenic differentiation in human bone marrow mesenchymal stem cells; it also significantly increased osteogenesis in vivo. This novel composite polymer scaffold has potential applications in bone tissue engineering.
引用
收藏
页码：35727 / 35737
页数：11
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